Fig. 2

Auditory Evoked Potentials. A Box plots showing the distribution of the latency and amplitude of the AEP components for TD, RTT, CDD, MDS, and FOXG1 participants. The peak latencies of AEP components were prolonged in participants with MDS and FOXG1 compared to participants with RTT and CDD. Statistical analyses were performed with Kruskal–Wallis tests and post-hoc analyses with Bonferroni-adjusted p values for significance (*p < 0.005). B Scatterplots illustrating the association between AEP P1-N1 amplitude and the severity measures (CSS and MBA) for RTT, CDD, MDS, and FOXG1 participants. P1-N1 amplitude was significantly associated with severity in RTT and CDD. C Scatterplots showing the association between the latency of select AEP components and the clinical severity measures in participants with RTT, CDD, MDS, and FOXG1. The latency of one or more of the AEP components was significantly associated with severity in CDD, MDS, and FOXG1. Statistical analyses for B-C were performed using linear regression (*p < 0.05). The grand average AEP waveforms are not included due to age-related shifts in peak latency, particularly for the TD group, which obscure comparisons of peak amplitudes