Visual memory profile in 22q11.2 microdeletion syndrome: are there differences in performance and neurobiological substrates between tasks linked to ventral and dorsal visual brain structures? A cross-sectional and longitudinal study
© The Author(s). 2016
Received: 13 June 2016
Accepted: 25 October 2016
Published: 10 November 2016
Children affected by the 22q11.2 deletion syndrome (22q11.2DS) have a specific neuropsychological profile with strengths and weaknesses in several cognitive domains. Specifically, previous evidence has shown that patients with 22q11.2DS have more difficulties memorizing faces and visual-object characteristics of stimuli. In contrast, they have better performance in visuo-spatial memory tasks. The first focus of this study was to replicate these results in a larger sample of patients affected with 22q11.2DS and using a range of memory tasks. Moreover, we analyzed if the deficits were related to brain morphology in the structures typically underlying these abilities (ventral and dorsal visual streams). Finally, since the longitudinal development of visual memory is not clearly characterized in 22q11.2DS, we investigated its evolution from childhood to adolescence.
Seventy-one patients with 22q11.2DS and 49 control individuals aged between 9 and 16 years completed the Benton Visual Retention Test (BVRT) and specific subtests assessing visual memory from the Children’s Memory Scale (CMS). The BVRT was used to compute spatial and object memory errors. For the CMS, specific subtests were classified into ventral, dorsal, and mixed subtests. Longitudinal data were obtained from a subset of 26 patients and 22 control individuals.
Cross-sectional results showed that patients with 22q11.2DS were impaired in all visual memory measures, with stronger deficits in visual-object memory and memory of faces, compared to visuo-spatial memory. No correlations between morphological brain impairments and visual memory were found in patients with 22q11.2DS. Longitudinal findings revealed that participants with 22q11.2DS made more object memory errors than spatial memory errors at baseline. This difference was no longer significant at follow-up.
Individuals with 22q11.2DS have impairments in visual memory abilities, with more pronounced difficulties in memorizing faces and visual-object characteristics. From childhood to adolescence, the visual cognitive profile of patients with 22q11.2DS seems globally stable even though some processes show an evolution with time. We hope that our results will help clinicians and caregivers to better understand the memory difficulties of young individuals with 22q11.2DS. This has a particular importance at school to facilitate recommendations concerning intervention strategies for these young patients.
Keywords22q11.2 deletion syndrome Visual memory Visual cognitive development Dorsal stream vulnerability hypothesis
Chromosome 22q11.2 deletion syndrome (22q11.2DS), also known as DiGeorge syndrome  or velocardiofacial syndrome , affects 1:2000 live births  and exceeds 1:1000 in referrals for prenatal diagnosis . In most cases, the syndrome results from a hemizygous 3-megabase microdeletion on the long arm of chromosome 22 . The physical phenotype of 22q11.2DS includes craniofacial and cardiovascular abnormalities, immunodeficiency, short stature, hypocalcaemia, and brain abnormalities . The syndrome is also frequently associated with psychiatric manifestations, such as attention-deficit/hyperactivity disorder, anxiety, mood disorders, and schizophrenia spectrum disorders emerging in adolescence and early adulthood .
Most studies report that individuals with 22q11.2DS show an intellectual level that falls in the borderline range (full-scale intellectual quotient (FSIQ) between 70 and 84), although a high heterogeneity is found in several cognitive domains . Patients affected by the syndrome have specific difficulties in processing visual information such as faces, scenes, or geometrical stimuli [8–10]. Several authors even described 22q11.2DS as being characterized by the non-verbal learning disability syndrome (NLD), although some aspects of the verbal domain remain also impaired [11, 12]. Anatomically, the visual information processing system is separated in two hierarchically organized and specialized networks within the brain: a “ventral stream” and a “dorsal stream” . Although the two pathways interact , the ventral stream, also known as the “what” pathway, relays information to the ventral and inferior temporal cortex including the fusiform gyrus and subserves object identification and face recognition [15, 16]. In contrast, the dorsal stream, known as the “where” pathway, relays information to the posterior parietal lobe and subserves spatial processing and visual control of spatially directed action [17, 18]. Memory abilities are also mediated by these two neural systems [19–22]. Activation of the inferior temporal cortex and the fusiform gyrus is observed when individuals have to retrieve and encode object identity of visual stimuli (e.g., shapes, colors, textures) or faces, whereas the parietal cortex and the supramarginal gyrus are activated during the encoding and retrieval of spatial localizations, object orientations, and volumetric properties of objects [23–25].
Previous studies highlighted significant visual memory impairments in individuals with 22q11.2DS [26, 27], such as difficulties in memorizing faces, shapes, line orientation, or spatial localizations [28–31]. Interestingly, the nature of the stimuli seems to influence the magnitude of the memory impairments. Evidences suggested that individuals with 22q11.2DS are more impaired in memory tasks related to the ventral stream compared to the tasks related the dorsal stream. Indeed, patients with 22q11.2DS have greater difficulties in memorizing faces or objects, whereas their memory of spatial localization seems partially impaired or even preserved [32–34]. However, these former studies have only included a limited number of tasks assessing the two streams and studied participants with a mean age ranging from 10 to 12.6 years. Further examination of this dissociation is therefore warranted. In addition, to our knowledge, no prior study investigated the relationship between these types of visual memory impairments in 22q11.2DS and their potential links with ventral and dorsal brain structures. On the neuronal level, abnormalities in temporal and parietal areas have been found in patients affected by the 22q11.2DS [35–38]. These abnormalities have been proposed to sustain the visual impairments observed in the syndrome.
In a developmental perspective, it is currently unknown whether these memory functions have an atypical development in 22q11.2DS. It has been shown that the cognitive profile is not stable in 22q11.2DS, with different patterns of strengths and weaknesses observed over time [39, 40]. In particular, although a global cognitive (FSIQ) decline has been found in patients affected, verbal and performance IQ scores were seen to evolve differently from childhood to adulthood, with performance IQ being more stable than verbal IQ [41, 42]. Looking more deeply within the non-verbal domain, Duijff et al.  showed a significant decline on the block design test in children with 22q11.2DS between 7.5 and 9.5 years, although other performance IQ subtests did not show any evolution. However, it is currently unclear how dorsal and ventral memory functions evolve during childhood in patients affected by the syndrome.
In the present study, we examined the capacity of subjects to memorize faces and spatial localizations. We also analyzed errors linked to failure of processing spatial or object characteristics of visual stimuli when subjects had to memorize and copy geometrical designs. Two kinds of investigation were carried out. The first set of hypothesis was made on a large sample of children and adolescents affected by the 22q11.2DS and on typically developing individuals aged between 9 and 16 years old. The first aim was to replicate the dissociation between tasks typically linked to the ventral stream and to the dorsal streams. Then, in light with a previous study showing that intellectual disability might have an impact on the neuropsychological profile of individuals with 22q11.2DS , additional analyses were performed to investigate the links between visual memory capacities and IQ measures. Finally, we also explored whether visual memory deficits in participants with 22q11.2DS were related to cerebral morphological alterations in the ventral (inferior and ventral temporal cortex) and dorsal brain areas (superior parietal cortex). Specifically, we made the following hypotheses: (1) individuals with 22q11.2DS would have lower scores in all visual memory tasks compared to typically developing individuals; (2) a specific visual memory profile would emerge, with greater impairments in tasks assessing the ventral stream; (3) in the 22q11.2DS group, IQ measures would be linked to visuo-spatial memory but not to visual-object memory; (4) altered visual memory would be related to changes in cortical morphology of underlying brain regions in participants with 22q11.2DS. Finally, as no previous study investigated this aspect in 22q11.2DS, the second aim of this study was to explore the longitudinal evolution of visual memory capacities between 9 and 16 years old (5).
Cross-sectional and longitudinal samples’ description of 22q11.2DS and TD participants
Mean age (SD)
Mean age (SD)
40 women (56 %)
25 women (51 %)
T1: 11.31 (1.11)
15 women (58 %)
T1: 10.75 (0.88)
13 women (60 %)
T2: 14.85 (1.01)
T2: 14.53 (0.58)
Descriptive statistics and group comparison statistical differences for global cognitive measures, BVRT errors, and CMS types of subtests
N = 71
N = 49
Statistical differences between groups
Global cognitive measures
p < 0.001
η2 = 0.71
p < 0.001
η2 = 0.63
p < 0.001
η2 = 0.56
Total of memory errors
p < 0.001
r = −0.42
Object memory errors
p < 0.001
r = −0.36
Spatial memory errors
p = 0.011
r = −0.23
Total of copy errors
p < 0.001
r = −0.42
Object copy errors
p < 0.001
r = −0.38
Spatial copy errors
p = 0.004
r = −0.26
CMS types of subtests
CMS ventral subtests
p < 0.001
η2 = 0.34
CMS dorsal subtests
p < 0.001
η2 = 0.22
CMS mixed subtests
p < 0.001
η2 = 0.19
The cross-sectional comparison group consisted of 49 typically developing individuals (TD) aged between 9 and 16 years. The TD group consisted of siblings of participants with 22q11.2DS and community controls. All participants were screened by an experienced psychiatrist to ensure that none of them had any past or present neurological or psychiatric disorder. TD participants with a FSIQ above 120 were excluded from the analyses in order to have a comparison sample representative of the general population. The TD and 22q11.2DS groups did not differ regarding age (t(118) = −0.77, p = 0.4) or gender distribution (x 2 = 0.33, df = 1, p = 0.57). The longitudinal control sample was constituted of 22 TD participants aged between 9 and 12 years at T1 and between 13 and 16 years at T2. Interval time between T1 and T2 was on average 3.7 years (SD = 0.7).
Within-group comparisons showed that FSIQ and Performance IQ (PIQ) did not differ between T1 and T2 (all p > 0.05). However, a significant decreased of verbal IQ (VIQ) was found in the 22q11.2DS group between the two evaluations (t(25) = 2.43, p = 0.023) (Table 4). All participants of the two groups included in longitudinal analyses did not differ from the cross-sectional samples in terms of gender distribution (all p > 0.05).
Benton Visual Retention Test
Parts A and C of the Benton Visual Retention Test (BVRT)  were administered in this order. In part A, the memory part, participants had to memorize ten designs printed on cards exposed for 10 s and reproduce them immediately. In part C, the copy part, participants had to copy the same designs while they remained in view. Errors were classified into five major categories: distortions, rotations, misplacements, size errors, and others. It should be noted that participants could make more than one error for the same design. To test the hypothesis that there are differences in the processing of ventral and dorsal information, error types were grouped into two main categories: spatial errors (misplacements and rotations errors) resulting in failure of processing visuo-spatial information and object errors (distortions and size errors) resulting in failure of processing visual-object information. The other types of errors (for example omissions or perseverations) were not included in the analysis as they are not related with spatial or object characteristics processing. The BVRT has been previously used in several pediatric populations, including children with learning disabilities [46, 47].
Children’s Memory Scale
We administered and analyzed subtests of the 9 to 16 years’ version of the Children’s Memory Scale (CMS) . In the Faces subtest, the participants were asked to pay attention and remember a set of 16 faces. These faces had then to be recognized in another set of 36 faces mixing targets and distractors. The dependent variables used were the number of faces correctly identified immediately after the presentation of the stimuli and after a 30-min delay. In the Dot localization subtest, the participants had to recall the location of dots on a grid. Each stimulus was presented for 2 s. The dependent variables used were the number of correct dot locations across four trials and the number of correct dot locations following a 30-min delay (one trial). In the Family Pictures subtest, the participants were shown four pictures displaying different family scenes (e.g., a picnic scene) for 10 s. Each scene contained four characters appearing in different locations (top right, top left, bottom right, or bottom left) and engaged in specific actions. The dependent variables were the number of correct characters, locations, and actions correctly recalled immediately and after a 30-min delay. Finally, in the Images Location subtest, the participants had to memorize locations of images (animals and vehicles) on a grid. Each stimulus was presented for 2 s. The dependent variables used were the number of correct images’ locations across 16 trials. No delayed recall was available in this subtest. To test our hypothesis about the presence of differences in the ventral or dorsal visual memory processing in 22q11.2DS, we grouped the variables into three main categories: The CMS dorsal subtests score was composed of the mean standard scores of the Dot Localization’s delayed and immediate recalls and the standard scores of the Image Localization’s subtests. The CMS ventral subtests score was composed of the mean standard scores of Faces’ delayed and immediate recalls together. Finally, a CMS mixed subtests score (i.e., subtests combining ventral and dorsal processing) was computed by averaging standard scores of the Family Picture’s delayed and immediate recalls. All the tests were performed by Master’s level psychologists according to the procedure described in the tests manuals [44, 45]. The CMS has been also previously used in 22q11.2DS [32, 49] and in children with learning disabilities .
Neuroimaging data acquisition
T1-weighted images were used to investigate brain morphological changes associated with impairments in visual memory in 22q11.2DS. Scans were acquired at the Geneva Center for Biomedical Imaging (CIBM) using a 1.5T and a 3T scanner. Scan parameters of the 1.5T Philips Intera scanner were 124 coronal slices, voxel size 0.94 × 0.94 × 1.5 mm, TR = 35 ms, TE = 6 ms, and flip angle = 45° and for the 3T Siemens Trio scanner, 192 coronal slices, voxel size 0.86 × 0.86 × 1.1 mm, TR = 2500, TE = 3 ms, and flip angle = 8°. High cross-scanner consistency of cortical thickness values was already reported in our previous study . Twelve participants with 22q11.2DS were excluded from the original group of 71 patients because of the absence (N = 5) or the bad quality (N = 7) of the T1-weighted acquisition. These 12 subjects were excluded from the neuroimaging analyses only.
Visual memory performances
Data were first checked for normality using the Kolmogorov-Smirnov test to conform to the assumptions of parametric tests. For the CMS variables, mixed, multivariate, and repeated-measures analyses of variance were used, followed by post hoc paired sample t tests to examine significant differences between pairs of variables. As the BVRT measures clearly violated normality assumptions in both groups of participants, non-parametric Mann-Whitney U tests for between-groups analyses and Wilcoxon signed-rank tests for within-groups analyses were performed. Thus, for the BVRT measures, medians were provided in results Tables 2 and 4. Spearman’s correlations were executed in the original cross-sectional sample to identify possible associations between the visual memory variables and global cognitive measures. Multiple comparisons corrections were applied for all the results using the Benjamini-Hochberg procedure .
Spearman’s correlations coefficients between visual memory scores and global cognitive measures (PIQ and VIQ) for the 71 participants with 22q11.2DS and the 49 TD individuals
CMS ventral subtests
CMS mixed subtests
CMS dorsal subtests
Object memory errors
Spatial memory errors
Correlations between ventral and dorsal memory and cortical morphology in participants with 22q11.2DS
After correction for multiple comparisons, BVRT object and spatial memory errors and CMS dorsal and ventral subtests scores did not show any significant correlation with values of cortical thickness and volume at the vertex-wise level. Similarly, at the ROI level, these measures were not significantly correlated with average cortical thickness, volume, and surface area in the superior parietal cortex and in the inferior and ventral temporal cortex (N = 59; all p > 0.05).
Intellectual quotients scores, BVRT and CMS memory performances for 22q11.2DS and TD participants at T1 (9–12 years) and T2 (13–16 years)
22q11.2DS participants (N = 26)
TD participants (N = 22)
Differences between T1 and T2
Differences between T1 and T2
Global cognitive measures
p = 0.023
Total memory errors
Object memory errors
p = 0.029
Spatial memory errors
CMS types of subtests
CMS ventral subtests
CMS dorsal subtests
CMS mixed subtests
Descriptive statistics at T1 and T2 for the CMS subtests categories in both groups are also reported in Table 4. A three-way mixed ANOVA with diagnosis as between factor and types of subtests and time as within factors was performed. There was no significant interaction between the type of subtests and time. There was also no significant main effect of time. However, a principal effect of groups was found (F(1,49) = 56.0, p < 0.001, partial η2 = 0.55). Group comparisons between 22q11.2DS and TD participants showed significant differences for all subtests at T1 and T2 (all p < 0.005, 0.19 < all partial η2 < 0.33), except for the CMS dorsal subtests at T2. Finally, one-way repeated measures analyses of variance (ANOVA) were conducted and showed no significant differences between CMS subtests categories in both groups either at T1 or at T2.
In this study, we investigated visual memory in a large sample of 71 children and adolescents with 22q11.2DS and 49 typically developed participants. Specifically, we examined the performance on different memory tasks typically sustained by the visual ventral and the dorsal brain streams. We also made additional analysis in order to investigate links between memory performances and intellectual functioning. Furthermore, we explored whether the observed pattern of visual memory impairments in participants with 22q11.2DS was related to the morphology of specific brain regions. Finally, in a longitudinal perspective, we also investigated if visual memory abilities in 22q11.2DS evolved from childhood to adolescence.
Our results showed that individuals with 22q11.2DS were impaired when they have to copy geometrical figures. This result is in line with studies highlighting impairments in visuo-constructive abilities in children affected by the 22q11.2DS [10, 57]. We did not observe any dissociation between object and spatial errors, indicating no greater impairments in visual-spatial or visual-object processing when participants with 22q11.2DS had to copy. Visuo-constructive abilities depend on the integrity of multiple processes such as perception, visuo-spatial organization, motor functioning, and motivation [58, 59]. Consequently, many impaired processes also observed in 22q11.2DS could underly the observed difficulties during the copy part, such as spatial working memory deficits , executive impairments , perceptual [34, 62, 63], and psychomotor deficits . Importantly, our results showed that both groups (22q11.2DS and TD) made more errors in the BVRT memory part compared to the copy part, indicating that the memory performance of individuals with 22q11.2DS is not only due to visuo-constructive impairments but also to memory contribution.
Nature of memory impairments in 22q11.2DS
Overall, patients with 22q11.2DS were impaired in all memory tasks compared to the comparison group but were more impaired in memory tasks linked to the ventral stream compared to the tasks linked to the dorsal stream. Although Bearden et al.  reported an inverse pattern with greater impairments in visuo-spatial memory, these findings are generally consistent with the literature in 22q11.2DS [32–34]. Interestingly, visual ventral and dorsal functions have been previously investigated in other developmental disorders. As highlighted by Atkinson and Braddick , most of these studies showed a dorsal stream networks vulnerability rather than a ventral vulnerability [65–71], leading to the proposition that there might be a specific dorsal vulnerability across developmental disorders. However, considering the results of the present study, it appears that not all developmental conditions show this dissociation. Vicari et al.  also showed that patients with Down syndrome, another condition associated with intellectual disability but showing visual processing impairments, have better performance on tasks assessing visuo-spatial memory compared to visual-object memory. Thus, it is possible that in different neurodevelopment disorders from different genetic etiologies such as 22q11.2DS, Down syndrome, Williams syndrome, or Fragile X syndrome, the visual streams are affected differently throughout development. Further research collecting data using the same experimental design in individuals with various genetic disorders is clearly needed to better characterize the contribution of the two streams in the cognitive profile of genetic syndromes.
Relationship between visual memory capacities and intellectual abilities in 22q11.2DS
A link between visual capacities and intellectual abilities was found in patients affected by the 22q11.2DS. In particular, visual-object memory was linked to IQ scores. In a recent study, Vicari et al.  found that short-term visuo-spatial memory but not visual-object memory was dependent of IQ. These conflicting results may be due to important differences between the tasks used in the two studies. In the present study, the tasks mainly relied on the encoding of visual aspects of stimuli, whereas Vicari et al.  used visuo-spatial and visual-object tasks both involving a serial number retrieval component, which is known to be impaired in 22q11.2DS . We further observed that the encoding of visual-object stimuli was not only associated with PIQ but also with VIQ. This might suggest, as it was also suggested by Bearden et al.  and in accordance with our clinical observations, that patients with 22q11.2DS may use alternative verbal strategies to encode visual information (e.g., verbalizing “square” to remember a square). As our results also showed that children and adolescents with 22q11.2DS improved their performance in visual-object memory from childhood to adolescence, it is possible that they learned to use verbal strategies to encode visual information throughout development. This hypothesis should be examined in greater detail in future studies, as this may have important implications for implementing adequate remediation strategies for learning difficulties in patients with 22q11.2DS.
Relationship between memory impairments and brain morphology
Contrary to our hypothesis, we did not observe any association between visual memory scores and cerebral alterations in the ventral and dorsal visual structures in patients with 22q11.2DS. This may suggest that the visual memory impairments observed in patients with 22q11.2DS are not related to brain morphological alterations, such as cortical volume, thickness, and surface area. However, other neuroimaging modalities, such as diffusion tensor imaging (DTI), may reveal the presence of a relationship between visual memory impairments and white matter connectivity in these patients. For example, Simon et al.  and Radoeva et al.  found that atypical structural connectivity in tracts belonging to the dorsal and ventral visual streams was correlated to visual processing impairments in patients with 22q11.2DS. Another possible reason explaining this lack of correlation is that the cognitive measures used in this study may not be specific enough, thus preventing to observe specific associations with areas of the ventral or dorsal stream . In particular and regarding the link between IQ and visual memory, it is likely that these tasks involve other brain areas, such as the frontal lobe. This may be especially true if participants used encoding strategies during the memory tasks .
Longitudinal development of cognitive profile in 22q11.2DS
From a developmental perspective, our results showed that whereas the capacities of patients with 22q11.2DS to memorize faces and spatial characteristics of visual stimuli were stable from childhood to adolescence, visual-object memory improved with time. This result can be interpreted in light of recent findings from the general population showing that the ventral and dorsal streams have different maturational rates. Indeed, the ventral areas keep developing until adulthood, whereas dorsal areas reach maturation earlier . Behavioral studies also found some evidence that functions linked to the ventral and the dorsal streams mature at different rates [76, 79, 80]. Thus, one interpretation of the improvement of visual-object processing in 22q11.2DS is that, like in healthy children, ventral and dorsal functions show a different maturational rate, with a temporal delay of the ventral stream development. In this study, no longitudinal neuroimaging data were analyzed due to the unavailability of an adequate sample size. Therefore, a follow-up study would be needed to further explore this hypothesis.
Limits and future directions
As mentioned earlier, the longitudinal analyses were performed in a relatively small sample of participants. However, we believe that using a longitudinal design limits the high inter-individual heterogeneity observed in patients with 22q11.2DS and therefore compensates for the small sample. One further limitation concerns the heterogeneity of the visual memory tasks used in the present study. Indeed, they involved different memory processes such as recollection or recognition that are potentially subserved by different brain networks. Besides, it would be interesting to investigate the influence of familiarity (“feeling of knowing”—a subjective experience of memory—versus “knowing”) on correct answers . Thus, analyzing the specific contribution of different memory processes to the observed findings would be important. No significant difference between short- and long-term memory was found in this study. In the field of 22q11.2DS, there is currently no data available regarding very long-term memory consolidation (up to several days). Therefore, the presence of accelerated long-term forgetting (i.e., information that is encoded and retained normally over delays of up to 30-min but then forgotten at an abnormally rapid rate over longer periods)  may be under-detected in individuals with 22q11.2DS. Finally, a previous study has shown that psychotic symptoms, especially negative symptoms, are associated with the severity of visual memory deficits in 22q11.2DS . As up to 80% of children and adolescents experience negative symptoms , it could be of great interest to further analyze their contribution to these results.
In summary, we investigated visual memory in individuals affected by the 22q11.2DS and in typically developed individuals aged from 9 to 16 years. We identified that the magnitude of deficits in patients with 22q11.2DS was not identical depending on the nature of the stimuli, with increased difficulties in memorizing faces or shapes compared to visuo-spatial information. In contrast to our hypothesis, no significant anatomical associations with memory deficits were observed in patients with 22q11.2DS. Finally, we identified that the cognitive difficulties experienced by children with 22q11.2DS are not static, as object memory improved during the course of development. Knowing that 22q11.2DS have specific visual memory deficits with difficulties such as processing the shapes of the stimuli is important for selecting proper revalidation strategies and improving everyday lives of children suffering from genetic syndromes . This has a particular impact for school materials that are essentially visual and that might be re-designed for patients with 22q11.2DS (for example simplifying visual information or promote verbal strategies in learning process).
22q11.2 deletion syndrome
Benton Visual Retention Test
Children’s Memory Scale
Diffusion tensor imaging
Full-scale intellectual quotient
Magnetic resonance imaging
Non-verbal learning disability syndrome
Performance intellectual quotient
Quantitative fluorescent polymerase chain reaction
Typically developed children
Verbal intellectual quotient
Wechsler Intelligence Scale for Children, third version
The authors would like to thank all the families who kindly volunteered for this study. We extend our acknowledgements to Alexandra Zaharia, Mathieu Mansion, Isaline Mottet, Elodie Cuche, Gloria Repond, Juliette Bleiker, Martina Franchini, and Déborah Badoud. Further thanks go to François Lazeyras, Frank Henry, and Yohann Ouvrier Buffet at the CIBM.
This study was supported by the Swiss National Fund to Professor Stephan Eliez (Grant numbers: FNS 324730_144260) and by the National Center of Competence in Research (NCCR) “SYNAPSY The Synaptic Bases of Mental Diseases” financed by the Swiss National Science Foundation. Maude Schneider was also supported by a personal grant by the Swiss National Science Foundation (Grant Number 162006).
Availability of data and materials
Please contact author for data requests.
MB, MS, BG, MD, and SE designed the study; MB, MS, MP, ES, SM, BG, MD, JM, and SE acquired the data; MB, MP, MS, and ES analyzed the data and undertook the statistical analyses; MB and MS wrote the first draft of the manuscript; all authors contributed to the interpretation of the results and the writing of the manuscript. All authors have approved the final manuscript.
The authors declare that they have no competing interests.
Consent for publication
The manuscript does not contain any individual person’s data in any form.
Ethics approval and consent to participate
All participants were recruited through advertisements in patient associations, newsletters, and through word of mouth in Switzerland, France, and Belgium. Written informed consent was obtained from participants and their parents under protocols approved by the Institutional Review Board of the Department of Psychiatry of the University of Geneva Medical School (Switzerland).
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