Fig. 1

Serotonin (5-HT) elicits a larger inhibitory outward current in prefrontal layer V pyramidal neurons from Gtf2ird1^−/− mice when compared to recordings from wildtype (WT) mice. a Schematic of a coronal section of prefrontal cortex. The vertical bar indicates the region in which whole-cell recordings of layer V pyramidal neurons were performed. b Representative voltage-clamp traces show that 5-HT application induces a larger inhibitory outward current in Gtf2ird1^−/− than WT, as measured at its peak. Gray bar denotes 5-HT application. c Bar graph of average peak amplitudes of outward currents. N values are bracketed; error bars represent the standard error and highlight the variance of the current distributions (* denotes P < 0.05)