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  1. Late talking (LT) in toddlers is a risk factor for language weakness that may interfere with the development of using language to regulate behavior and emotion and contribute to the development of behavior pro...

    Authors: Hsin-Hui Lu, Jeng-Dau Tsai and Feng-Ming Tsao
    Citation: Journal of Neurodevelopmental Disorders 2022 14:38
    Content type: Research Published on:

  2. In over half of pediatric cases, ADHD presents with comorbidities, and often, it is unclear whether the symptoms causing impairment are due to the comorbidity or the underlying ADHD. Comorbid conditions increa...

    Authors: Isabella Slaby, Heather S. Hain, Debra Abrams, Frank D. Mentch, Joseph T. Glessner, Patrick M. A. Sleiman and Hakon Hakonarson
    Citation: Journal of Neurodevelopmental Disorders 2022 14:37
    Content type: Research Published on:

  3. Speech is the most common modality through which language is communicated, and delayed, disordered, or absent speech production is a hallmark of many neurodevelopmental and genetic disorders. Yet, speech is no...

    Authors: Karen V. Chenausky and Helen Tager-Flusberg
    Citation: Journal of Neurodevelopmental Disorders 2022 14:36
    Content type: Review Published on:

  4. Down syndrome regression disorder is a symptom cluster consisting of neuropsychiatric regression without cause. This study evaluated the incidence of neurodiagnostic abnormalities in individuals with Down synd...

    Authors: Jonathan D. Santoro, Rebecca Partridge, Runi Tanna, Dania Pagarkar, Mellad Khoshnood, Mustafa Rehmani, Ryan M. Kammeyer, Grace Y. Gombolay, Kristen Fisher, Allison Conravey, Jane El-Dahr, Alison L. Christy, Lina Patel, Melanie A. Manning, Heather Van Mater, Michael S. Rafii…
    Citation: Journal of Neurodevelopmental Disorders 2022 14:35
    Content type: Research Published on:

  5. SYNGAP1-related intellectual disability (ID) is a recently described neurodevelopmental disorder that is caused by pathogenic variation in the SYNGAP1 gene. To date, the behavioural characteristics of this disor...

    Authors: Damien Wright, Aisling Kenny, Sarah Eley, Andrew G. McKechanie and Andrew C. Stanfield
    Citation: Journal of Neurodevelopmental Disorders 2022 14:34
    Content type: Research Published on:

  6. Regulator of calcineurin 1 (RCAN1) is overexpressed in Down syndrome (DS), but RCAN1 levels are also increased in Alzheimer’s disease (AD) and normal aging. AD is highly comorbid among individuals with DS and is...

    Authors: Helen Wong, Jordan M. Buck, Curtis Borski, Jessica T. Pafford, Bailey N. Keller, Ryan A. Milstead, Jessica L. Hanson, Jerry A. Stitzel and Charles A. Hoeffer
    Citation: Journal of Neurodevelopmental Disorders 2022 14:33
    Content type: Research Published on:

  7. Autism spectrum disorder (ASD) is a complex neurodevelopmental condition characterized by restricted, repetitive behavior, and impaired social communication and interactions. However, significant challenges re...

    Authors: Mengge Zhao, James Havrilla, Jacqueline Peng, Madison Drye, Maddie Fecher, Whitney Guthrie, Birkan Tunc, Robert Schultz, Kai Wang and Yunyun Zhou
    Citation: Journal of Neurodevelopmental Disorders 2022 14:32
    Content type: Research Published on:

  8. Rett syndrome (RTT) is a neurodevelopmental disorder most often related to a pathogenic variant in the X-linked MECP2 gene. Internalizing behaviors appear to be common, but standard methods of diagnosing anxiety ...

    Authors: Caroline B. Buchanan, Jennifer L. Stallworth, Aubin E. Joy, Rebekah E. Dixon, Alexandra E. Scott, Arthur A. Beisang, Timothy A. Benke, Daniel G. Glaze, Richard H. Haas, Peter T. Heydemann, Mary D. Jones, Jane B. Lane, David N. Lieberman, Eric D. Marsh, Jeffrey L. Neul, Sarika U. Peters…
    Citation: Journal of Neurodevelopmental Disorders 2022 14:31
    Content type: Research Published on:

  9. Attention Deficit Hyperactivity Disorder (ADHD) is the most prevalent childhood neurodevelopmental disorder. It shares some genetic risk with Autism Spectrum Disorder (ASD), and the conditions often occur toge...

    Authors: Irene O. Lee, David H. Skuse, Paul A. Constable, Fernando Marmolejo-Ramos, Ludvig R. Olsen and Dorothy A. Thompson
    Citation: Journal of Neurodevelopmental Disorders 2022 14:30
    Content type: Research Published on:

  10. Autism spectrum disorder is a neurodevelopmental disorder, affecting 1–2% of children. Studies have revealed genetic and cellular abnormalities in the brains of affected individuals, leading to both regional a...

    Authors: Maider Astorkia, Herbert M. Lachman and Deyou Zheng
    Citation: Journal of Neurodevelopmental Disorders 2022 14:29
    Content type: Research Published on:

  11. Intellectual and Developmental Disabilities (IDDs), such as Down syndrome, Fragile X syndrome, Rett syndrome, and autism spectrum disorder, usually manifest at birth or early childhood. IDDs are characterized ...

    Authors: Chirag Gupta, Pramod Chandrashekar, Ting Jin, Chenfeng He, Saniya Khullar, Qiang Chang and Daifeng Wang
    Citation: Journal of Neurodevelopmental Disorders 2022 14:28
    Content type: Review Published on:

  12. The development of advanced genetic technologies has resulted in rapid identification of genetic etiologies of neurodevelopmental disorders (NDDs) and has transformed the classification and diagnosis of variou...

    Authors: Juliana Simon, Carly Hyde, Vidya Saravanapandian, Rujuta Wilson, Charlotte Distefano, Aaron Besterman and Shafali Jeste
    Citation: Journal of Neurodevelopmental Disorders 2022 14:27
    Content type: Research Published on:

  13. Neonatal hypoxic brain injury is a major cause of intellectual and developmental disability. Hypoxia causes neuronal dysfunction and death in the developing cerebral cortex due to excitotoxic Ca2+-influx. In the ...

    Authors: Panagiotis Kratimenos, Abhya Vij, Robinson Vidva, Ioannis Koutroulis, Maria Delivoria-Papadopoulos, Vittorio Gallo and Aaron Sathyanesan
    Citation: Journal of Neurodevelopmental Disorders 2022 14:26
    Content type: Research Published on:

  14. SATB2-associated syndrome (SAS) is a multisystem neurodevelopmental disorder characterised by intellectual disability, speech delay, and craniofacial anomalies. Although the clinical presentation of SAS is wel...

    Authors: Stacey Bissell, Chris Oliver, Joanna Moss, Mary Heald, Jane Waite, Hayley Crawford, Vishakha Kothari, Lauren Rumbellow, Grace Walters and Caroline Richards
    Citation: Journal of Neurodevelopmental Disorders 2022 14:25
    Content type: Research Published on:

  15. Computational phenotypes are most often combinations of patient billing codes that are highly predictive of disease using electronic health records (EHR). In the case of rare diseases that can only be diagnose...

    Authors: Cartik Kothari, Siddharth Srivastava, Youssef Kousa, Rima Izem, Marcin Gierdalski, Dongkyu Kim, Amy Good, Kira A. Dies, Gregory Geisel, Hiroki Morizono, Vittorio Gallo, Scott L. Pomeroy, Gwenn A. Garden, Lisa Guay-Woodford, Mustafa Sahin and Paul Avillach
    Citation: Journal of Neurodevelopmental Disorders 2022 14:24
    Content type: Research Published on:

  16. Carriers of the FMR1 premutation are at increased risk of developing a late-onset progressive neurodegenerative disease, fragile X-associated tremor/ataxia syndrome (FXTAS), characterized by intention tremor, gai...

    Authors: Jessica Famula, Emilio Ferrer, Randi J. Hagerman, Flora Tassone, Andrea Schneider, Susan M. Rivera and David Hessl
    Citation: Journal of Neurodevelopmental Disorders 2022 14:23
    Content type: Research Published on:

  17. The recent National Institute of Health (NIH) INCLUDE (INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE) initiative has bolstered capacity for the current increase in cl...

    Authors: Nicole T. Baumer, Mara L. Becker, George T. Capone, Kathleen Egan, Juan Fortea, Benjamin L. Handen, Elizabeth Head, James E. Hendrix, Ruth Y. Litovsky, Andre Strydom, Ignacio E. Tapia and Michael S. Rafii
    Citation: Journal of Neurodevelopmental Disorders 2022 14:22
    Content type: Review Published on:

  19. Deficits in procedural memory have been proposed to account for the language deficits in specific language impairment (SLI). A key aspect of the procedural deficit hypothesis (PDH) account of SLI is that decla...

    Authors: Julia L. Evans, Mandy J. Maguire and Marisa L. Sizemore
    Citation: Journal of Neurodevelopmental Disorders 2022 14:20
    Content type: Research Published on:

  20. A wide variety of model systems and experimental techniques can provide insight into the structure and function of the human brain in typical development and in neurodevelopmental disorders. Unfortunately, thi...

    Authors: Alexander Li Cohen
    Citation: Journal of Neurodevelopmental Disorders 2022 14:19
    Content type: Review Published on:

  21. There is substantial variability in adaptive skills among individuals with Down syndrome. Few studies, however, have focused on the early developmental period or on the potential sources of variability in adap...

    Authors: Emily K. Schworer, Anna J. Esbensen, Vivian Nguyen, Lauren Bullard, Deborah J. Fidler, Lisa A. Daunhauer, Carolyn B. Mervis, Angela M. Becerra, Leonard Abbeduto and Angela John Thurman
    Citation: Journal of Neurodevelopmental Disorders 2022 14:18
    Content type: Research Published on:

  22. Attention deficit hyperactivity disorder (ADHD) is a common childhood behavioral condition that globally affects an average of around 5% of children and is associated with several adverse life outcomes. Comorb...

    Authors: Maria M. Lilja, Emil Sandblom, Paul Lichtenstein, Eva Serlachius, Clara Hellner, Jyoti Bhagia and Linda Halldner
    Citation: Journal of Neurodevelopmental Disorders 2022 14:17
    Content type: Research Published on:

  23. Although survival rates for infants born extremely preterm (gestation < 28 weeks) have improved significantly in recent decades, neurodevelopmental impairment remains a major concern. Children born extremely p...

    Authors: Weifang Liu, Quan Sun, Le Huang, Arjun Bhattacharya, Geoffery W. Wang, Xianming Tan, Karl C. K. Kuban, Robert M. Joseph, T. Michael O’Shea, Rebecca C. Fry, Yun Li and Hudson P. Santos Jr
    Citation: Journal of Neurodevelopmental Disorders 2022 14:16
    Content type: Research Published on:

  24. Neurofibromatosis type 1 (NF1) is considered a model of neurodevelopmental disorder because of the high frequency of learning deficits, especially developmental coordination disorder. In neurodevelopmental dis...

    Authors: Eloïse Baudou, Federico Nemmi, Patrice Peran, Fabien Cignetti, Melody Blais, Stéphanie Maziero, Jessica Tallet and Yves Chaix
    Citation: Journal of Neurodevelopmental Disorders 2022 14:15
    Content type: Research Published on:

  25. Triple X syndrome (47,XXX) is a relatively common sex chromosomal aneuploidy characterized by the presence of a supernumerary X chromosome in females and has been associated with a variable cognitive, behaviou...

    Authors: Chaira Serrarens, Maarten Otter, Bea C. M. Campforts, Constance T. R. M. Stumpel, Henk Jansma, Thérèse A. M. J. van Amelsvoort and Claudia Vingerhoets
    Citation: Journal of Neurodevelopmental Disorders 2022 14:14
    Content type: Research Published on:

  26. Tuberous sclerosis complex (TSC)–associated neuropsychiatric disorders (TAND) is an umbrella term for the behavioural, psychiatric, intellectual, academic, neuropsychological and psychosocial manifestations of...

    Authors: Stephanie Vanclooster, Stacey Bissell, Agnies M. van Eeghen, Nola Chambers, Liesbeth De Waele, Anna W. Byars, Jamie K. Capal, Sebastián Cukier, Peter Davis, Jennifer Flinn, Sugnet Gardner-Lubbe, Tanjala Gipson, Tosca-Marie Heunis, Dena Hook, J. Christopher Kingswood, Darcy A. Krueger…
    Citation: Journal of Neurodevelopmental Disorders 2022 14:13
    Content type: Review Published on:

  27. To explore the associations between childhood infections and subsequent diagnoses of autism spectrum disorder (ASD), intellectual disability (ID), and their co-occurrence.

    Authors: Håkan Karlsson, Hugo Sjöqvist, Martin Brynge, Renee Gardner and Christina Dalman
    Citation: Journal of Neurodevelopmental Disorders 2022 14:12
    Content type: Research Published on:

  28. Tbr1 encodes a T-box transcription factor and is considered a high confidence autism spectrum disorder (ASD) gene. Tbr1 is expressed in the postmitotic excitatory neurons of the deep neocortical layers 5 and 6. ...

    Authors: Siavash Fazel Darbandi, Andrew D. Nelson, Emily Ling-lin Pai, Kevin J. Bender and John L. R. Rubenstein
    Citation: Journal of Neurodevelopmental Disorders 2022 14:11
    Content type: Research Published on:

  29. There are currently no pharmacological therapies to address the intellectual disability associated with Down syndrome. Excitatory/inhibitory imbalance has been hypothesized to contribute to impairments in cogn...

    Authors: Celia Goeldner, Priya S. Kishnani, Brian G. Skotko, Julian Lirio Casero, Joerg F. Hipp, Michael Derks, Maria-Clemencia Hernandez, Omar Khwaja, Sian Lennon-Chrimes, Jana Noeldeke, Sabine Pellicer, Lisa Squassante, Jeannie Visootsak, Christoph Wandel, Paulo Fontoura and Xavier Liogier d’Ardhuy
    Citation: Journal of Neurodevelopmental Disorders 2022 14:10
    Content type: Research Published on:

  30. The concomitant role of the Central Executive, the Saliency and the Social Cognition networks in autism spectrum disorder (ASD) in demanding ecological tasks remains unanswered. We addressed this question usin...

    Authors: Susana Mouga, Isabel Catarina Duarte, Cátia Café, Daniela Sousa, Frederico Duque, Guiomar Oliveira and Miguel Castelo-Branco
    Citation: Journal of Neurodevelopmental Disorders 2022 14:9
    Content type: Research Published on:

  31. The genetic disorder tuberous sclerosis complex (TSC) is frequently accompanied by the development of neuropsychiatric disorders, including autism spectrum disorder and intellectual disability, with varying de...

    Authors: Anatoly Korotkov, Mark J. Luinenburg, Alessia Romagnolo, Till S. Zimmer, Jackelien van Scheppingen, Anika Bongaarts, Diede W. M. Broekaart, Jasper J. Anink, Caroline Mijnsbergen, Floor E. Jansen, Wim van Hecke, Wim G. Spliet, Peter C. van Rijen, Martha Feucht, Johannes A. Hainfellner, Pavel Krsek…
    Citation: Journal of Neurodevelopmental Disorders 2022 14:8
    Content type: Research Published on:

  32. Women who carry a premutation allele of the FMR1 gene are at increased vulnerability to an array of age-related symptoms and disorders, including age-related decline in select cognitive skills. However, the risk ...

    Authors: Jessica Klusek, Amanda Fairchild, Carly Moser, Marsha R. Mailick, Angela John Thurman and Leonard Abbeduto
    Citation: Journal of Neurodevelopmental Disorders 2022 14:7
    Content type: Research Published on:

  33. Differences in face processing in individuals with ASD is hypothesized to impact the development of social communication skills. This study aimed to characterize the neural correlates of face processing in 12-...

    Authors: Joshua Glauser, Carol L. Wilkinson, Laurel J. Gabard-Durnam, Boin Choi, Helen Tager-Flusberg and Charles A. Nelson
    Citation: Journal of Neurodevelopmental Disorders 2022 14:6
    Content type: Research Published on:

  34. RASopathies are genetic syndromes that result from pathogenic variants in the RAS-MAPK cellular signaling pathway. These syndromes, which include neurofibromatosis type 1, Noonan syndrome, cardiofaciocutaneous...

    Authors: Allison M. H. Foy, Rebekah L. Hudock, Ryan Shanley and Elizabeth I. Pierpont
    Citation: Journal of Neurodevelopmental Disorders 2022 14:5
    Content type: Research Published on:

  35. Social communication is a key area of difficulty in fragile X syndrome (FXS) and there are not yet adequate outcome measurement tools. Appropriate outcome measures for FXS have been identified as a key area of...

    Authors: Rebecca Shaffer, Angela John Thurman, Lucienne Ronco, Diego Cadavid, Shane Raines and So Hyun Kim
    Citation: Journal of Neurodevelopmental Disorders 2022 14:4
    Content type: Research Published on:

  36. This implementation feasibility study was conducted to determine whether an evidence-based parent-implemented distance-learning intervention model for young children at high likelihood of having ASD could be i...

    Authors: Sally J. Rogers, Aubyn Stahmer, Meagan Talbott, Gregory Young, Elizabeth Fuller, Melanie Pellecchia, Angela Barber and Elizabeth Griffith
    Citation: Journal of Neurodevelopmental Disorders 2022 14:3
    Content type: Research Published on:

  37. Imitation skills play a crucial role in social cognitive development from early childhood. Many studies have shown a deficit in imitation skills in children with autism spectrum disorders (ASD). Little is know...

    Authors: Irène Pittet, Nada Kojovic, Martina Franchini and Marie Schaer
    Citation: Journal of Neurodevelopmental Disorders 2022 14:2
    Content type: Research Published on:

  38. Phosphatase and tensin homologue (PTEN) is a cancer suppressor gene. Constitutional mutations affecting this gene are associated with several conditions, collectively termed PTEN hamartoma tumour syndromes (PHTS...

    Authors: Katherine Cummings, Alice Watkins, Chris Jones, Renuka Dias and Alice Welham
    Citation: Journal of Neurodevelopmental Disorders 2022 14:1
    Content type: Review Published on:

  40. Sex chromosome aneuploidies (SCAs) are a collectively common family of genetic disorders that increase the risk for neuropsychiatric and cognitive impairment. Beyond being important medical disorders in their ...

    Authors: Srishti Rau, Ethan T. Whitman, Kimberly Schauder, Nikhita Gogate, Nancy Raitano Lee, Lauren Kenworthy and Armin Raznahan
    Citation: Journal of Neurodevelopmental Disorders 2021 13:61
    Content type: Research Published on:

  41. Tuberous Sclerosis Complex (TSC) is associated with a range of neuropsychiatric difficulties, appropriately termed TSC-Associated Neuropsychiatric Disorders (TAND). The objectives of the study were to analyze ...

    Authors: Samuel Alperin, Darcy A. Krueger, David N. Franz, Karen D. Agricola, Gabrielle Stires, Paul S. Horn and Jamie K. Capal
    Citation: Journal of Neurodevelopmental Disorders 2021 13:60
    Content type: Research Published on:

  42. Early-life stress can leave persistent epigenetic marks that may modulate vulnerability to psychiatric conditions later in life, including anxiety, depression and stress-related disorders. These are complex di...

    Authors: María Abellán-Álvaro, Oliver Stork, Carmen Agustín-Pavón and Mónica Santos
    Citation: Journal of Neurodevelopmental Disorders 2021 13:59
    Content type: Research Published on:

  43. The current study used eye tracking to investigate attention and recognition memory in Phelan-McDermid syndrome (PMS), a rare genetic disorder characterized by intellectual disability, motor delays, and a high...

    Authors: Sylvia B. Guillory, Victoria Z. Baskett, Hannah E. Grosman, Christopher S. McLaughlin, Emily L. Isenstein, Emma Wilkinson, Jordana Weissman, Bari Britvan, M. Pilar Trelles, Danielle B. Halpern, Joseph D. Buxbaum, Paige M. Siper, A. Ting Wang, Alexander Kolevzon and Jennifer H. Foss-Feig
    Citation: Journal of Neurodevelopmental Disorders 2021 13:58
    Content type: Research Published on:

  44. Early identification of autism spectrum disorder (ASD) provides an opportunity for early intervention and improved developmental outcomes. The use of electroencephalography (EEG) in infancy has shown promise i...

    Authors: Fleming C. Peck, Laurel J. Gabard-Durnam, Carol L. Wilkinson, William Bosl, Helen Tager-Flusberg and Charles A. Nelson
    Citation: Journal of Neurodevelopmental Disorders 2021 13:57
    Content type: Research Published on:

  46. Autism spectrum disorder (ASD) is a neurodevelopmental condition, which is characterized by clinical heterogeneity and high heritability. Core symptoms of ASD include deficits in social communication and inter...

    Authors: Jan Philipp Delling and Tobias M. Boeckers
    Citation: Journal of Neurodevelopmental Disorders 2021 13:55
    Content type: Review Published on:

  47. Language plays a major role in human behavior. For this reason, neurodevelopmental and psychiatric disorders in which linguistic ability is impaired could have a big impact on the individual’s social interacti...

    Authors: Ron Nudel, Vivek Appadurai, Alfonso Buil, Merete Nordentoft and Thomas Werge
    Citation: Journal of Neurodevelopmental Disorders 2021 13:54
    Content type: Research Published on:

  48. Phelan McDermid syndrome (PMS) is a neurogenetic condition associated with a high prevalence of intellectual disability (ID) and autism spectrum disorder (ASD). This study provides a more comprehensive and qua...

    Authors: Siddharth Srivastava, Emma Condy, Erin Carmody, Rajna Filip-Dhima, Kush Kapur, Jonathan A. Bernstein, Elizabeth Berry-Kravis, Craig M. Powell, Latha Soorya, Audrey Thurm, Joseph D. Buxbaum, Mustafa Sahin and Alexander Kolevzon
    Citation: Journal of Neurodevelopmental Disorders 2021 13:53
    Content type: Research Published on:

  49. Turner syndrome (TS) is a genetic disorder associated with complete or partial absence of an X chromosome affecting approximately 1/2000 live female births. Available evidence suggests that, in the school-age ...

    Authors: Debra B. Reinhartsen, Emil Cornea, Margaret DeRamus, Angelia B. Waitt, Rebecca Edmondson Pretzel, Rebecca C. Knickmeyer, Marsha L. Davenport, John H. Gilmore and Stephen R. Hooper
    Citation: Journal of Neurodevelopmental Disorders 2021 13:52
    Content type: Research Published on:

  50. Turner syndrome is the result of the partial or complete absence of an X chromosome in phenotypic girls. This can cause an array of medical and developmental difficulties. The intelligence quotient in females ...

    Authors: Hanna Björlin Avdic, Agnieszka Butwicka, Anna Nordenström, Catarina Almqvist, Agneta Nordenskjöld, Hedvig Engberg and Louise Frisén
    Citation: Journal of Neurodevelopmental Disorders 2021 13:51
    Content type: Research Published on:
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Journal of Neurodevelopmental Disorders

ISSN: 1866-1955

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