Research
Although significant impairments in the affective and cognitive facets of social cognition have been highlighted in patients with 22q11.2 deletion syndrome (22q11DS) in previous studies, these domains have nev...
Journal of Neurodevelopmental Disorders 2017 9:35
Published on: 25 September 2017
Research
Existing literature draws links between social attention and socio-behavioural profiles in neurodevelopmental disorders. Fragile X syndrome (FXS) is associated with a known socio-behavioural phenotype of socia...
Journal of Neurodevelopmental Disorders 2017 9:9
Published on: 25 September 2017
Research
Alterations in brain development during infancy may precede the behavioral manifestation of developmental disorders. Infants at increased risk for autism are also at increased risk for other developmental diso...
Journal of Neurodevelopmental Disorders 2017 9:34
Published on: 13 September 2017
Research
Extreme shyness and social anxiety is reported to be characteristic of adolescents and adults with Cornelia de Lange syndrome (CdLS); however, the nature of these characteristics is not well documented. In thi...
Journal of Neurodevelopmental Disorders 2017 9:33
Published on: 11 September 2017
Research
Recent research has demonstrated that subclinical autistic traits of parents amplify the effects of deleterious mutations in the causation of autism spectrum disorder (ASD) in their offspring. Here, we examine...
Journal of Neurodevelopmental Disorders 2017 9:32
Published on: 5 September 2017
Research
The FMR1 premutation affects 1:291 women and is associated with a range of cognitive, affective, and physical health complications, including deficits in pragmatic language (i.e., social language). This study inv...
Journal of Neurodevelopmental Disorders 2017 9:31
Published on: 24 August 2017
Research
The aim of this study was to examine executive functioning in adolescents and adults with Cornelia de Lange syndrome (CdLS) to identify a syndrome and age-related profile of cognitive impairment.
Journal of Neurodevelopmental Disorders 2017 9:29
Published on: 15 August 2017
Research
Gamma-aminobutyric acid (GABA) system deficits are integral to the pathophysiologic development of fragile X syndrome (FXS). Ganaxolone, a GABAA receptor positive allosteric modulator, is hypothesized to improve ...
Journal of Neurodevelopmental Disorders 2017 9:26
Published on: 2 August 2017
Review
Preterm birth is associated with an increased risk of adverse neurologic, psychiatric, and cognitive outcomes. The brain circuits involved in processing social information are critical to all of these domains,...
Journal of Neurodevelopmental Disorders 2017 9:27
Published on: 19 July 2017
Erratum
Journal of Neurodevelopmental Disorders 2017 9:30
Published on: 17 July 2017
The original article was published in Journal of Neurodevelopmental Disorders 2017 9:17
Review
ADHD (attention deficit hyperactivity disorder) is a common neurodevelopmental disorder. There has been extensive clinical and basic research in the field of ADHD over the past 20 years, but the mechanisms und...
Journal of Neurodevelopmental Disorders 2017 9:25
Published on: 10 July 2017
Review
Many children with autism and other neurodevelopmental disorders undergo expensive, time-consuming behavioral interventions that often yield only modest improvements. The development of adjunctive intervention...
Journal of Neurodevelopmental Disorders 2017 9:20
Published on: 4 July 2017
Research
Both children with autism spectrum disorders (ASD) and children with specific language impairment (SLI) have been shown to have difficulties with grammatical processing. A comparison of these two populations w...
Journal of Neurodevelopmental Disorders 2017 9:28
Published on: 4 July 2017
Review
Epileptic encephalopathies represent a particularly severe form of epilepsy, associated with cognitive and behavioral deficits, including impaired social-communication and restricted, repetitive behaviors that...
Journal of Neurodevelopmental Disorders 2017 9:23
Published on: 23 June 2017
Research
A substantial amount of work has examined language abilities in young children with specific language impairment (SLI); however, our understanding of the developmental trajectory of language impairment is limi...
Journal of Neurodevelopmental Disorders 2017 9:22
Published on: 14 June 2017
Research
Arbaclofen improved multiple abnormal phenotypes in animal models of fragile X syndrome (FXS) and showed promising results in a phase 2 clinical study. The objective of the study is to determine safety and eff...
Journal of Neurodevelopmental Disorders 2017 9:3
Published on: 12 June 2017
Research
Fragile X Syndrome (FXS) occurs as a result of a silenced fragile X mental retardation 1 gene (FMR1) and subsequent loss of fragile X mental retardation protein (FMRP) expression. Loss of FMRP alters excitatory/i...
Journal of Neurodevelopmental Disorders 2017 9:6
Published on: 12 June 2017
Review
Fragile X syndrome (FXS) has been the neurodevelopmental disorder with the most active translation of preclinical breakthroughs into clinical trials. This process has led to a critical assessment of outcome me...
Journal of Neurodevelopmental Disorders 2017 9:14
Published on: 12 June 2017
Review
Our understanding of fragile X syndrome (FXS) pathophysiology continues to improve and numerous potential drug targets have been identified. Yet, current prescribing practices are only symptom-based in order t...
Journal of Neurodevelopmental Disorders 2017 9:7
Published on: 12 June 2017
Editorial
Journal of Neurodevelopmental Disorders 2017 9:21
Published on: 12 June 2017
Research
A small percentage of people with autism spectrum disorders (ASD) have alterations in chromosome 15q11.2-q3, the critical region for Prader-Willi syndrome (PWS). Data are limited, however, on the rates and cha...
Journal of Neurodevelopmental Disorders 2017 9:18
Published on: 5 June 2017
Research
Autism spectrum disorder (ASD) is a genetically and phenotypically heterogeneous disorder. Promising initiatives utilizing interdisciplinary characterization of ASD suggest phenotypic subtypes related to speci...
Journal of Neurodevelopmental Disorders 2017 9:24
Published on: 26 May 2017
Research
Children with the neurogenetic disorder neurofibromatosis type 1 (NF1) often have problems with learning and behaviour. In both parent reports and neuropsychological assessment, motor problems are reported in ...
Journal of Neurodevelopmental Disorders 2017 9:19
Published on: 19 May 2017
Research
Clinicians have qualitatively described rhythmic delta activity as a prominent EEG abnormality in individuals with Angelman syndrome, but this phenotype has yet to be rigorously quantified in the clinical popu...
Journal of Neurodevelopmental Disorders 2017 9:17
Published on: 8 May 2017
The Erratum to this article has been published in Journal of Neurodevelopmental Disorders 2017 9:30
Research
Autonomic dysfunction is implicated in a range of psychological conditions, including depression and anxiety. The fragile X mental retardation-1 (FMR1) premutation is a common genetic mutation that affects ~1:150...
Journal of Neurodevelopmental Disorders 2017 9:16
Published on: 2 May 2017
