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  1. Autism spectrum disorder (ASD) impacts an individual’s ability to socialize, communicate, and interact with, and adapt to, the environment. Over the last two decades, research has focused on early identificati...

    Authors: Rebecca Grzadzinski, Dima Amso, Rebecca Landa, Linda Watson, Michael Guralnick, Lonnie Zwaigenbaum, Gedeon Deák, Annette Estes, Jessica Brian, Kevin Bath, Jed Elison, Leonard Abbeduto, Jason Wolff and Joseph Piven

    Citation: Journal of Neurodevelopmental Disorders 2021 13:49

    Content type: Review

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  2. Down syndrome (DS) is the most common genetic cause of intellectual disability (ID) worldwide. Understanding electrophysiological characteristics associated with DS provides potential mechanistic insights into...

    Authors: Sarah Hamburg, Daniel Bush, Andre Strydom and Carla M. Startin

    Citation: Journal of Neurodevelopmental Disorders 2021 13:48

    Content type: Research

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  3. Individuals with Fragile X syndrome (FXS) and autism spectrum disorder (ASD) exhibit an array of symptoms, including sociability deficits, increased anxiety, hyperactivity, and sensory hyperexcitability. It is...

    Authors: Patricia S. Pirbhoy, Carrie R. Jonak, Rashid Syed, Donovan A. Argueta, Pedro A. Perez, Mark B. Wiley, Keon Hessamian, Jonathan W. Lovelace, Khaleel A. Razak, Nicholas V. DiPatrizio, Iryna M. Ethell and Devin K. Binder

    Citation: Journal of Neurodevelopmental Disorders 2021 13:47

    Content type: Research

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  4. Disturbances in sensory function are an important clinical feature of neurodevelopmental disorders such as fragile X syndrome (FXS). Evidence also directly connects sensory abnormalities with the clinical expr...

    Authors: Olivier Perche, Fabien Lesne, Alain Patat, Susanne Raab, Roy Twyman, Robert H. Ring and Sylvain Briault

    Citation: Journal of Neurodevelopmental Disorders 2021 13:45

    Content type: Research

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  5. Adults with autism spectrum disorder (ASD) have lower engagement in their communities, higher rates of unemployment/underemployment, and continued difficulties with challenging behavior compared to their neuro...

    Authors: Leann Smith DaWalt, Emily Hickey, Rebekah Hudock, Amy Esler and Marsha Mailick

    Citation: Journal of Neurodevelopmental Disorders 2021 13:44

    Content type: Research

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  6. Autism spectrum disorders (ASD) are associated with altered sensory processing and perception. Scalp recordings of electrical brain activity time-locked to sensory events (event-related potentials; ERPs) provi...

    Authors: Shlomit Beker, John J. Foxe, John Venticinque, Juliana Bates, Elizabeth M. Ridgeway, Roseann C. Schaaf and Sophie Molholm

    Citation: Journal of Neurodevelopmental Disorders 2021 13:43

    Content type: Research

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  7. Social interaction often occurs in noisy environments with many extraneous sensory stimuli. This is especially relevant for youth with autism spectrum disorders (ASD) who commonly experience sensory over-respo...

    Authors: Genevieve Patterson, Kaitlin K. Cummings, Jiwon Jung, Nana J. Okada, Nim Tottenham, Susan Y. Bookheimer, Mirella Dapretto and Shulamite A. Green

    Citation: Journal of Neurodevelopmental Disorders 2021 13:42

    Content type: Research

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  8. Preterm birth (<37 weeks) adversely affects development in behavioural, cognitive and mental health domains. Heightened rates of autism are identified in preterm populations, indicating that prematurity may co...

    Authors: Catherine Laverty, Andrew Surtees, Rory O’Sullivan, Daniel Sutherland, Christopher Jones and Caroline Richards

    Citation: Journal of Neurodevelopmental Disorders 2021 13:41

    Content type: Research

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  9. CDKL5 deficiency disorder (CDD) is associated with refractory infantile onset epilepsy, global developmental delay, and variable features that include sleep, behavioral disturbances, and movement disorders. Cu...

    Authors: Heather E. Olson, Carolyn I. Daniels, Isabel Haviland, Lindsay C. Swanson, Caitlin A. Greene, Anne Marie M. Denny, Scott T. Demarest, Elia Pestana-Knight, Xiaoming Zhang, Ahsan N. Moosa, Andrea Fidell, Judith L. Weisenberg, Bernhard Suter, Cary Fu, Jeffrey L. Neul, Alan K. Percy…

    Citation: Journal of Neurodevelopmental Disorders 2021 13:40

    Content type: Research

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  10. Although autism spectrum disorders (ASD) are among the most heritable of all neuropsychiatric syndromes, most affected children are born to unaffected parents. Recently, we reported an average increase of 3–5% ov...

    Authors: Natasha Marrus, Tychele N. Turner, Elizabeth Forsen, Drew Bolster, Alison Marvin, Andrew Whitehouse, Laura Klinger, Christina A. Gurnett and J. N. Constantino

    Citation: Journal of Neurodevelopmental Disorders 2021 13:39

    Content type: Research

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  11. Families of young children with autism spectrum disorder (ASD) frequently experience barriers to accessing evidence-based early intervention services. Telemedicine presents an opportunity to increase access to...

    Authors: Laura L. Corona, J. Alacia Stainbrook, Kathleen Simcoe, Liliana Wagner, Bethena Fowler, Amy S. Weitlauf, A. Pablo Juárez and Zachary Warren

    Citation: Journal of Neurodevelopmental Disorders 2021 13:38

    Content type: Research

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  12. The idea that alterations in gut-microbiome-brain axis (GUMBA)-mediated communication play a crucial role in human brain disorders like autism remains a topic of intensive research in various labs. Gastrointes...

    Authors: Safa Salim, Ayesha Banu, Amira Alwa, Swetha B. M. Gowda and Farhan Mohammad

    Citation: Journal of Neurodevelopmental Disorders 2021 13:37

    Content type: Review

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  13. Approximately 30% of children diagnosed with autism remain minimally verbal past age 5. Interventions are often effective in increasing spoken communication for some of these children. Clinical and research de...

    Authors: Nancy C. Brady, Christine Kosirog, Kandace Fleming and Lindsay Williams

    Citation: Journal of Neurodevelopmental Disorders 2021 13:36

    Content type: Research

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  14. Conceptual knowledge frameworks termed schemas facilitate memory formation and are posited to support flexible behavior. In adults, the medial temporal lobe (MTL) and medial prefrontal cortex (mPFC) trade-off in ...

    Authors: Kevin M. Cook, Xiaozhen You, Joseph Bradley Cherry, Junaid S. Merchant, Mary Skapek, Meredith D. Powers, Cara E. Pugliese, Lauren Kenworthy and Chandan J. Vaidya

    Citation: Journal of Neurodevelopmental Disorders 2021 13:35

    Content type: Research

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  15. This paper reviews a candidate biomarker for ASD, the M50 auditory evoked response component, detected by magnetoencephalography (MEG) and presents a position on the roles and opportunities for such a biomarke...

    Authors: Timothy P. L. Roberts, Emily S. Kuschner and J. Christopher Edgar

    Citation: Journal of Neurodevelopmental Disorders 2021 13:34

    Content type: Review

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  16. Identification of ASD biomarkers is a key priority for understanding etiology, facilitating early diagnosis, monitoring developmental trajectories, and targeting treatment efforts. Efforts have included explor...

    Authors: Emily Neuhaus, Sarah J. Lowry, Megha Santhosh, Anna Kresse, Laura A. Edwards, Jack Keller, Erin J. Libsack, Veronica Y. Kang, Adam Naples, Allison Jack, Shafali Jeste, James C. McPartland, Elizabeth Aylward, Raphael Bernier, Susan Bookheimer, Mirella Dapretto…

    Citation: Journal of Neurodevelopmental Disorders 2021 13:33

    Content type: Research

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  17. Individuals with autism spectrum disorder (ASD) show deficits processing sensory feedback to reactively adjust ongoing motor behaviors. Atypical reliance on visual and somatosensory feedback each have been rep...

    Authors: Robin L. Shafer, Zheng Wang, James Bartolotti and Matthew W. Mosconi

    Citation: Journal of Neurodevelopmental Disorders 2021 13:32

    Content type: Research

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  18. Transmission of SARS-CoV-2 in schools primarily for typically developing children is rare. However, less is known about transmission in schools for children with intellectual and developmental disabilities (ID...

    Authors: Michael R. Sherby, Tyler J. Walsh, Albert M. Lai, Julie A. Neidich, Joyce E. Balls-Berry, Stephanie M. Morris, Richard Head, Christopher G. Prener, Jason G. Newland and Christina A. Gurnett

    Citation: Journal of Neurodevelopmental Disorders 2021 13:31

    Content type: Research

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  19. Prenatal exposure to air pollutants is associated with increased risk for neurodevelopmental and neurodegenerative disorders. However, few studies have identified transcriptional changes related to air polluta...

    Authors: Amin Haghani, Jason I. Feinberg, Kristy C. Lewis, Christine Ladd-Acosta, Richard G. Johnson, Andrew E. Jaffe, Constantinos Sioutas, Caleb E. Finch, Daniel B. Campbell, Todd E. Morgan and Heather E. Volk

    Citation: Journal of Neurodevelopmental Disorders 2021 13:30

    Content type: Research

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  20. Children in Flint, Michigan, have experienced myriad sociodemographic adversities exacerbated by the Flint water crisis. To help inform child-focused prevention and intervention efforts, we aimed to describe p...

    Authors: Shuting Zheng, Somer L. Bishop, Tiffany Ceja, Mona Hanna-Attisha and Kaja LeWinn

    Citation: Journal of Neurodevelopmental Disorders 2021 13:29

    Content type: Research

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  21. Irritability is a common and impairing occurrence in autistic youth, yet the underlying mechanisms are not well-known. In typically developing populations, differences in frustration response have been suggest...

    Authors: Virginia Carter Leno, Georgia Forth, Susie Chandler, Philippa White, Isabel Yorke, Tony Charman, Andrew Pickles and Emily Simonoff

    Citation: Journal of Neurodevelopmental Disorders 2021 13:27

    Content type: Research

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  22. Phelan-McDermid syndrome (PMS) is a rare genetic disorder compromising the 22q13 terminal region and affecting SHANK3, a gene crucial to the neurobehavioural phenotype and strongly linked to autism (ASD) and inte...

    Authors: Mónica Burdeus-Olavarrieta, Antonia San José-Cáceres, Alicia García-Alcón, Javier González-Peñas, Patricia Hernández-Jusdado and Mara Parellada-Redondo

    Citation: Journal of Neurodevelopmental Disorders 2021 13:26

    Content type: Research

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  23. Prader-Willi syndrome (PWS) is a rare neurodevelopmental genetic disorder associated with a characteristic behavioral phenotype that includes severe hyperphagia and a variety of other behavioral challenges suc...

    Authors: Lauren Schwartz, Assumpta Caixàs, Anastasia Dimitropoulos, Elisabeth Dykens, Jessica Duis, Stewart Einfeld, Louise Gallagher, Anthony Holland, Lauren Rice, Elizabeth Roof, Parisa Salehi, Theresa Strong, Bonnie Taylor and Kate Woodcock

    Citation: Journal of Neurodevelopmental Disorders 2021 13:25

    Content type: Review

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  24. Neurodevelopmental disorders (NDDs), including autism spectrum disorder (ASD) and intellectual disability (ID), are common diagnoses with highly heterogeneous phenotypes and etiology. The genetics-first approa...

    Authors: Anne B. Arnett, Tianyun Wang, Evan E. Eichler and Raphael A. Bernier

    Citation: Journal of Neurodevelopmental Disorders 2021 13:24

    Content type: Review

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  25. Pathways leading to psychosis in 22q11.2 deletion syndrome (22q11.2DS) have been the focus of intensive research during the last two decades. One of the common clinical risk factors for the evolution of psycho...

    Authors: Tyler M. Moore, Deby Salzer, Carrie E. Bearden, Monica E. Calkins, Wendy R. Kates, Leila Kushan, Robert Sean Gallagher, Dafna Sofrin Frumer, Ronnie Weinberger, Donna M. McDonald-McGinn, Raquel E. Gur and Doron Gothelf

    Citation: Journal of Neurodevelopmental Disorders 2021 13:23

    Content type: Research

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  26. Sensory modulation difficulties are common in children with conditions such as Autism Spectrum Disorder (ASD) and could contribute to other social and non-social symptoms. Positing a causal role for sensory pr...

    Authors: Jannath Begum-Ali, Anna Kolesnik-Taylor, Isabel Quiroz, Luke Mason, Shruti Garg, Jonathan Green, Mark H. Johnson and Emily J. H. Jones

    Citation: Journal of Neurodevelopmental Disorders 2021 13:22

    Content type: Research

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  27. To assess the prevalence of symptoms of depression, anxiety, and stress among mothers of children with autism spectrum disorders (ASD), type 1 diabetes (DM), and typical development (TD), in a geographical are...

    Authors: Ahmed Malalla Al Ansari, Mohamed Ismael Janahi, Abdulrahman J. AlTourah, Haitham Ali Jahrami and Mansour Bin Rajab

    Citation: Journal of Neurodevelopmental Disorders 2021 13:21

    Content type: Research

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  28. Many children with developmental language disorders (DLD) have well-documented weaknesses in vocabulary. In recent years, investigators have explored the nature of these weaknesses through the use of novel wor...

    Authors: Laurence B. Leonard, Sharon L. Christ, Patricia Deevy, Jeffrey D. Karpicke, Christine Weber, Eileen Haebig, Justin B. Kueser, Sofía Souto and Windi Krok

    Citation: Journal of Neurodevelopmental Disorders 2021 13:20

    Content type: Research

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  29. The association between autism spectrum disorder and hydrocephalus is not well understood, despite demonstrated links between autism spectrum disorder and cerebrospinal fluid abnormalities. Based on the hypoth...

    Authors: Tina Nørgaard Munch, Paula Louise Hedley, Christian Munch Hagen, Marie Bækvad-Hansen, Jonas Bybjerg-Grauholm, Jakob Grove, Merete Nordentoft, Anders Dupont Børglum, Preben Bo Mortensen, Thomas Mears Werge, Mads Melbye, David Michael Hougaard and Michael Christiansen

    Citation: Journal of Neurodevelopmental Disorders 2021 13:19

    Content type: Research

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  30. FOXP1 syndrome is a neurodevelopmental disorder caused by mutations or deletions that disrupt the forkhead box protein 1 (FOXP1) gene, which encodes a transcription factor important for the early development of m...

    Authors: Reymundo Lozano, Catherine Gbekie, Paige M. Siper, Shubhika Srivastava, Jeffrey M. Saland, Swathi Sethuram, Lara Tang, Elodie Drapeau, Yitzchak Frank, Joseph D. Buxbaum and Alexander Kolevzon

    Citation: Journal of Neurodevelopmental Disorders 2021 13:18

    Content type: Review

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  31. Nearly all persons with Down syndrome will show pathology of Alzheimer’s disease in their 40s. There is a critical need for studies to identify early biomarkers of these various pathological changes of Alzheim...

    Authors: Austin Bazydlo, Matthew Zammit, Minjie Wu, Douglas Dean, Sterling Johnson, Dana Tudorascu, Ann Cohen, Karly Cody, Beau Ances, Charles Laymon, William Klunk, Shahid Zaman, Benjamin Handen, Andrew Alexander, Bradley Christian and Sigan Hartley

    Citation: Journal of Neurodevelopmental Disorders 2021 13:17

    Content type: Research

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  32. There is a high degree of inter- and intra-individual variability observed within the phenotype of Down syndrome. The Down Syndrome Cognition Project was formed to capture this variability by developing a larg...

    Authors: Marie Moore Channell, Laura J. Mattie, Debra R. Hamilton, George T. Capone, E. Mark Mahone, Stephanie L. Sherman, Tracie C. Rosser, Roger H. Reeves and Luther G. Kalb

    Citation: Journal of Neurodevelopmental Disorders 2021 13:16

    Content type: Research

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  33. 22q11.2 deletion syndrome (22q11DS) is a common recurrent neurogenetic condition associated with elevated risk for developmental neuropsychiatric disorders and intellectual disability. Children and adults with...

    Authors: Rhideeta Jalal, Aarti Nair, Amy Lin, Ariel Eckfeld, Leila Kushan, Jamie Zinberg, Katherine H. Karlsgodt, Tyrone D. Cannon and Carrie E. Bearden

    Citation: Journal of Neurodevelopmental Disorders 2021 13:15

    Content type: Research

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  34. Tuberous sclerosis complex (TSC), a multi-system genetic disorder often associated with autism spectrum disorder (ASD), is caused by mutations of TSC1 or TSC2, which lead to constitutive overactivation of mammali...

    Authors: Tomas Petrasek, Iveta Vojtechova, Ondrej Klovrza, Klara Tuckova, Cestmir Vejmola, Jakub Rak, Anna Sulakova, Daniel Kaping, Nadine Bernhardt, Petrus J. de Vries, Jakub Otahal and Robert Waltereit

    Citation: Journal of Neurodevelopmental Disorders 2021 13:14

    Content type: Research

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  35. The purpose of this study was to evaluate expressive language sampling (ELS) as a procedure for generating spoken language outcome measures for treatment research in Down syndrome (DS). We addressed (a) feasib...

    Authors: Angela John Thurman, Jamie O. Edgin, Stephanie L. Sherman, Audra Sterling, Andrea McDuffie, Elizabeth Berry-Kravis, Debra Hamilton and Leonard Abbeduto

    Citation: Journal of Neurodevelopmental Disorders 2021 13:13

    Content type: Research

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  36. Disorders of gene dosage can significantly increase risk for psychopathology, but outcomes vary greatly amongst carriers of any given chromosomal aneuploidy or sub-chromosomal copy number variation (CNV). One ...

    Authors: Kathleen E. Wilson, Ari M. Fish, Catherine Mankiw, Anastasia Xenophontos, Allysa Warling, Ethan Whitman, Liv Clasen, Erin Torres, Jonathan Blumenthal and Armin Raznahan

    Citation: Journal of Neurodevelopmental Disorders 2021 13:12

    Content type: Research

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  37. Social anxiety is highly prevalent in neurotypical children and children with fragile X syndrome (FXS). FXS is a genetic syndrome that is characterized by intellectual disability and an increased risk for auti...

    Authors: Conner J. Black, Abigail L. Hogan, Kayla D. Smith and Jane E. Roberts

    Citation: Journal of Neurodevelopmental Disorders 2021 13:11

    Content type: Research

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  38. Motor deficits such as abnormal gait are an underappreciated yet characteristic phenotype of many neurodevelopmental disorders (NDDs), including Williams Syndrome (WS) and Neurofibromatosis Type 1 (NF1). Compa...

    Authors: Rachel M. Rahn, Claire T. Weichselbaum, David H. Gutmann, Joseph D. Dougherty and Susan E. Maloney

    Citation: Journal of Neurodevelopmental Disorders 2021 13:10

    Content type: Research

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  39. Spinal muscular atrophy (SMA) is a chronic, neuromuscular disease characterized by degeneration of spinal cord motor neurons, resulting in progressive muscular atrophy and weakness. SMA1 is the most severe for...

    Authors: Grazia Zappa, Antonella LoMauro, Giovanni Baranello, Emilia Cavallo, Priscilla Corti, Chiara Mastella and Maria Antonella Costantino

    Citation: Journal of Neurodevelopmental Disorders 2021 13:9

    Content type: Research

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  40. Neuroimaging research on individuals who have autism spectrum disorder (ASD) has historically been limited primarily to those with age-appropriate cognitive and language performance. Children with limited abil...

    Authors: Emily S. Kuschner, Mina Kim, Luke Bloy, Marissa Dipiero, J. Christopher Edgar and Timothy P. L. Roberts

    Citation: Journal of Neurodevelopmental Disorders 2021 13:8

    Content type: New method

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  41. Individuals with autism spectrum disorder (ASD) often experience elevated stress during social interactions and may have difficulty forming and maintaining peer relationships. The autonomic nervous system (ANS...

    Authors: Rachael A. Muscatello, Simon N. Vandekar and Blythe A. Corbett

    Citation: Journal of Neurodevelopmental Disorders 2021 13:6

    Content type: Research

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  42. Autism spectrum disorder (ASD) is associated with hyper- and/or hypo-sensitivity to sensory input. Spontaneous alpha power, which plays an important role in shaping responsivity to sensory information, is redu...

    Authors: Sarah Pierce, Girija Kadlaskar, David A. Edmondson, Rebecca McNally Keehn, Ulrike Dydak and Brandon Keehn

    Citation: Journal of Neurodevelopmental Disorders 2021 13:5

    Content type: Research

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  43. Adults and adolescents with autism spectrum disorders show greater difficulties comprehending speech in the presence of noise. Moreover, while neurotypical adults use visual cues on the mouth to help them unde...

    Authors: Rochelle S. Newman, Laura A. Kirby, Katie Von Holzen and Elizabeth Redcay

    Citation: Journal of Neurodevelopmental Disorders 2021 13:4

    Content type: Research

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  44. The Clinical Global Impression-Severity (CGI-S) and CGI-Improvement (CGI-I) scales are widely accepted tools that measure overall disease severity and change, synthesizing the clinician’s impression of the glo...

    Authors: Alexander Kolevzon, Pamela Ventola, Christopher J. Keary, Gali Heimer, Jeffrey L. Neul, Mathews Adera and Judith Jaeger

    Citation: Journal of Neurodevelopmental Disorders 2021 13:3

    Content type: New method

    Published on:

  45. Research with rodents is crucial for expanding our understanding of genetic and environmental risk factors for neurodevelopmental disorders (NDD). However, there is growing concern about the number of animal s...

    Authors: Jessica A. Jiménez and Mark J. Zylka

    Citation: Journal of Neurodevelopmental Disorders 2021 13:2

    Content type: Review

    Published on:

  46. Atypicalities in tactile processing are reported in autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) but it remains unknown if they precede and associate with the traits of th...

    Authors: Elena Serena Piccardi, Jannath Begum Ali, Emily J. H. Jones, Luke Mason, Tony Charman, Mark H. Johnson and Teodora Gliga

    Citation: Journal of Neurodevelopmental Disorders 2021 13:1

    Content type: Research

    Published on:

  47. Clinical studies found that medication for attention-deficit/hyperactivity disorder (ADHD) is effective in coexisting autism spectrum disorder (ASD), but current research is based on small clinical studies mai...

    Authors: Viktoria Johansson, Sven Sandin, Zheng Chang, Mark J. Taylor, Paul Lichtenstein, Brian M. D’Onofrio, Henrik Larsson, Clara Hellner and Linda Halldner

    Citation: Journal of Neurodevelopmental Disorders 2020 12:44

    Content type: Research

    Published on:

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