Atypical development of the executive attention network in children with chromosome 22q11.2 deletion syndrome

Table 4 Surviving factors and interactions

Selected factors^a	Mixed model estimates of fixed effects on LnAdjRT
Selected factors^a	Estimate (β) (×10²)^b	Standard error (×10²)	Significance (p)^c	Description (e^β followed by specified significant condition)
Age	−0.651	0.0868	<0.001	0.65% benefit per month of age.
Age × flanker	−0.145	0.0410	0.009	0.15% benefit per month on incongruent flankers.
Age × cue				No significant specific interactions.
Flanker	26.9	5.44	<0.001	30.8% cost on incongruent flankers.
Diagnosis	13.4	4.15	0.039	14.3% cost to those with 22q11.2DS.
Diagnosis × flanker				No significant specific interactions.
Gender				No significant specific interactions.
Gender × flanker	7.2	3.51	0.011	7.5% cost to males on incongruent flankers
Cue × flanker				No significant specific interactions.
Variance
Residual	1.95	0.09		2.0% of the total variation
Participants	3.43	0.54		3.5% of the total variation

^aDetermined by type III sum of squares (see “Methods” for criteria)
^bSome parameters were set to 0 because they are used as the reference parameter for modeling. They are diagnosis = typically developing, gender = female, flanker = single, and cue = valid. For interactions, if any condition tested contains a reference, that estimate is set to 0
^cFor clarity, parameter estimates are reported only if the factor it modifies significantly contributed to the model. For example, age × flanker survived entry criteria, but of the age × flanker interactions, only the age by incongruent condition significantly contributed to the model and is presented here. Despite inclusion of the cue × flanker interaction in the model due to a type III sum of squares significance of p = 0.042, none of the 12 specific cue × flanker possibilities significantly contributed to the mixed linear model. This may be due to the large number of paired comparisons to be considered or their colinearity. p Values are Bonferroni adjusted for 23 comparisons

ISSN: 1866-1955