Fig. 2
From: Regulation of molecular pathways in the Fragile X Syndrome: insights into Autism Spectrum Disorders
mRNA translational repression. a General mRNA translation is repressed by binding of 4E-BP1/2/3 (red) to the cap-binding protein eIF4E (blue). b Specific translational regulation through sequence specific regulatory elements. mRNAs harboring the Cytoplasmic Polyadenylation Element (CPE) are recruited by CPEB (purple) and their translation repressed by Maskin/Neuroguidin (light blue); c mRNAs carrying the Bruno-Responsive Element (BRE) are bound by Bruno (yellow) and their translation inhibited by Cup (orange). d FMRP (green) can either directly interact with the mRNAs or e recruit them to the inhibitory complex by base-pairing with the non coding RNA BC1. In this case, the translation repression occurs via the eIF4E-BP CYFIP1 (violet)