Figure 5
From: Developmental patterns of DR6 in normal human hippocampus and in Down syndrome
DR6 immunoreactivity (IR) in control and Down syndrome (DS) adult hippocampus. A-B: adult hippocampus of control (A) and DS (B), showing DR6 IR throughout the different hippocampal subfields (DG, dentate gyrus). C, D: high magnification of CA1 (C) and DG (D) in DS showing strong DR6 expression in dystrophic neurites in amyloid plaques (arrows). E: amyloid precursor protein (APP) IR is detected in the dystrophic neurites of plaques (arrows) in DS. F: colocalization of APP and DR6 in dystrophic neurites (purple; arrows) in DS. G: localization of hyperphosphorylated Tau and DR6 in dystrophic neurites (purple; arrows and insert) in DS. H: Confocal image showing accumulation of DR6 IR (red) around β-amyloid deposits (green) in DS. Hematoxylin counterstain shows blue nuclei (A-E). Scale bar (shown in H): A-B, 400 μm; C-E, 80 μm; F-H, 40 μm.