Figure 6
From: Developmental patterns of DR6 in normal human hippocampus and in Down syndrome
Caspase 6 (Casp6) immunoreactivity (IR) in controls and Down syndrome (DS) adult hippocampus. A- B: control hippocampus (B, CA1) without detectable Casp6 IR, without accumulation in neurons. C- F: DS hippocampus showing increased Casp6 IR throughout the hippocampus; D-F show high magnification of CA1 with strong IR in tangles (arrows in E), neuropil threads, and dystrophic neurites in plaques (arrowheads in E and arrows in F). G: colocalization of Casp6 and APP in dystrophic neurites (purple; arrows and insert). H: colocalization of Casp6 and DR6 in dystrophic neurites (purple; arrows and insert). Hematoxylin counterstain shows blue nuclei (A-F). Scale bar (shown in H): A,C, 400 μm; B, D, 160 μm; E, 80 μm; F, 40 μm. G-H, 25 μm.