Divergent structural brain abnormalities between different genetic subtypes of children with Prader–Willi syndrome

Table 4 Focal cortical white matter volumes in children with PWS and healthy controls

	PWS				Control		P value between groups	P_corrvalue DEL versus control	P_corrvalue mUPD versus control	P_corrvalue mUPD versus DEL
	DEL		mUPD
	Mean	SD	Mean	SD	Mean	SD
Left pars orbitalis	0.00057	0.00008	0.00055	0.00008	0.00064	0.00006	0.033	0.09	0.06	ns
Left superior frontal	0.01242	0.0012	0.01101	0.00074	0.01284	0.00032	0.002	ns	0.001	0.026
Left precuneus	0.00679	0.00098	0.00566	0.00096	0.00652	0.00065	0.025	ns	ns	0.021
Right pars orbitalis	0.0008	0.00013	0.00070	0.00008	0.00088	0.00011	0.005	ns	0.003	0.127
Right pars triangularis	0.00217	0.00031	0.00190	0.00035	0.0023	0.00038	0.014	ns	0.043	ns
Right caudal anterior cingulate	0.00235	0.00024	0.00237	0.00015	0.00219	0.00034	0.011	ns	ns	0.008
Right posterior cingulate	0.00319	0.00025	0.00198	0.00022	0.00314	0.00026	0.008	ns	0.044	0.010
Right precuneus	0.00736	0.00125	0.00282	0.00089	0.00678	0.00079	0.042	ns	ns	0.036

All measures presented in table are corrected for TIV. P_corr values that did not survive the Bonferroni correction are included. DEL, deletion; mUPD, maternal uniparental disomy; ns, not significant; PWS, Prader–Willi syndrome; SD, standard deviation; TIV, total intracranial volume.

ISSN: 1866-1955