Skip to main content

Table 5 Linear trend analyses across difficulty levels: ASD group

From: The neural correlates of visuo-spatial working memory in children with autism spectrum disorder: effects of cognitive load

Linear trend analyses across difficulty levels for children with ASD

 

Voxels

MNI Coordinates

Z value

P value

Hem.

Region

  

x

y

z

    

Regions where activation increases with difficulty (increasing BOLD signal)

1816

28

−52

−14

3.61

8.94 × 10−7

R

Fusiform gyrus

 

X

26

−84

12

3.42

 

R

Middle occipital gyrus

 

1449

−26

−88

8

3.52

1.09 × 10−5

L

Middle occipital gyrus

 

X

−20

−68

−14

3.17

 

L

Fusiform gyrus

Regions where activation decreases with difficulty (decreasing BOLD signal)

2210

10

−50

36

−3.80

5.96 × 10−8

R

Posterior cingulate cortex

 

X

−6

−68

24

−2.91

 

L

Posterior cingulate cortex

 

1308

12

54

0

−4.06

3.02 × 10−5

R

Medial frontal gyrus

 

X

−10

40

8

−2.98

 

R

Medial frontal gyrus/Anterior cingulate cortex

 

642

18

36

44

−3.64

7.00 × 10−3

R

Superior frontal gyrus

 

509

60

−56

−2

−3.63

2.89 × 10−3

R

Middle temporal gyrus

  1. Results from linear trend analyses from D3 to D6 for children with ASD. Areas that increased as a function of difficulty level (A) are associated with WM and visuo-spatial processing, whereas areas that decreased as a function of difficulty level (B) are associated with the default mode network. MNI coordinates represent the peak Z value of the cluster; X peak local maximas within cluster.