Table 1 Acquired developmental milestones: gross and fine motor
From: Developmental delay in Rett syndrome: data from the natural history study
Skill | Classic (N = 542, 5 without answers) | Atypical better (N = 50) | Atypical poorer (N = 46, 1 without answers) | ||||||
|---|---|---|---|---|---|---|---|---|---|
Acquired | Lost | Retained | Acquired | Lost | Retained | Acquired | Lost | Retained | |
Gross motor | |||||||||
Rolling | 95 (511) | 23 (118) | 77 (414) | 96 (48) | 6.3 (3)* | 96 (48) ◊ | 87 (39) ● | 28 (11) | 62 (28)* |
Sit with support | 97 (520) | 12 (62) | 88 (473) | 100 (50) | 2.0 (1)● | 100 (50) | 93 (42) | 19 (8) | 84 (38) |
Sit alone | 80 (427) | 16 (70) | 69 (369) | 94 (47)* | 0 (0) | 94 (47) ◊ | 31 (14) ◊ | 21 (3) | 24 (11) ◊ |
Crawl | 69 (370) | 38 (139) | 45 (244) | 88 (43)* | 7.0 (3) ◊ | 82 (41) ◊ | 22 (10) ◊ | 40 (4) | 13 (6) ◊ |
Pull to stand | 62 (331) | 34 (112) | 43 (231) | 92 (46) ◊ | 4.3 (2) ◊ | 88 (44) ◊ | 16 (7) ◊ | 43 (3) | 8.9 (4) ◊ |
Walk with help | 79 (422) | 13 (54) | 71 (383) | 94 (47) * | 4.3 (2) | 92 (46) ◊ | 31 (14) ◊ | 14 (2) | 27 (12) ◊ |
Walk alone | 53 (284) | 14 (41) | 47 (253) | 78 (39) ◊ | 13 (5) | 70 (35) ◊ | 6.7 (3) ◊ | 67 (2) | 2.2 (1) ◊ |
Climb Steps | 20 (106) | 26 (27) | 15 (81) | 62 (31) ◊ | 23 (7) | 52 (26) ◊ | 0 (0) | 0 (0) | 0 (0) |
Ride tricycle | 4 (22) | 32 (7) | 3.2 (17) | 16 (8)* | 0 (0) | 16 (8) * | 2.2 (1) | 0 (0) | 2.2 (1) |
Fine motor | |||||||||
Hold bottle | 85 (455) | 49 (223) | 46 (248) | 98 (49)* | 12 (6) ◊ | 92 (46) ◊ | 71 (32) ● | 34 (11) | 53 (24) |
Reach | 97 (523) | 49 (255) | 58 (314) | 100 (50) | 10 (5) ◊ | 94 (47) ◊ | 91 (41) ● | 27(11)* | 76 (34)* |
Transfer | 78 (418) | 61 (257) | 69 (370) | 96 (48) ◊ | 17 (8) ◊ | 86 (43) ◊ | 71 (32) | 38(12)* | 49 (22)* |
Pincer grasp | 74 (396) | 72 (285) | 24 (128) | 90 (45)* | 36(16) ◊ | 66 (33) ◊ | 42 (19) ◊ | 32 (6) ◊ | 29 (13) |
Finger feed | 91 (489) | 56 (276) | 45 (242) | 96 (48) | 10 (5) ◊ | 90 (45) ◊ | 64 (29) ● | 28 (8)* | 47 (21) |