Table 1 Risk of full mutation expansion using total CGG length, AGG, age from 525 premutation mothers

55

20

0.4% (0.1%, 2.3%)

0.1% (0%, 0.9%)

0% (0%, 0.1%)

0.40%

30

1.6% (0.4%, 6.6%)

0.5% (0.1%, 2.6%)

0% (0%, 0.3%)

1.60%

40

6.5% (1.5%, 24.3%)

2.3% (0.5%, 9.9%)

0.1% (0%, 1.2%)

6.40%

60

20

1.5% (0.3%, 7.3%)

0.5% (0.1%, 2.9%)

0% (0%, 0.3%)

1.50%

30

6.4% (2%, 18.8%)

2.2% (0.6%, 7.7%)

0.1% (0%, 0.9%)

6.30%

40

23.1% (7.3%, 53.5%)

9.1% (2.6%, 27.4%)

0.5% (0.1%, 3.7%)

22.60%

65

20

6.3% (1.7%, 21.2%)

2.2% (0.5%, 9%)

0.1% (0%, 0.9%)

6.20%

30

22.9% (9.8%, 44.7%)

9% (3.4%, 21.6%)

0.5% (0.1%, 2.7%)

22.40%

40

56.6% (27.4%, 81.8%)

30.2% (12%, 58%)

2.1% (0.4%, 11.5%)

54.50%

70

20

22.7% (8%, 49.7%)

8.9% (2.7%, 25.7%)

0.5% (0.1%, 2.8%)

22.20%

30

56.3% (34.7%, 75.7%)

30% (15.8%, 49.4%)

2.1% (0.5%, 8.5%)

54.20%

40

85% (62.1%, 95.1%)

65.3% (38.6%, 84.9%)

8.6% (1.9%, 31.8%)

76.40%

75

20

56% (28.9%, 80%)

29.8% (12%, 56.8%)

2.1% (0.5%, 8.9%)

53.90%

30

84.8% (69.1%, 93.3%)

65% (46.3%, 80%)

8.5% (2.6%, 24.3%)

76.30%

40

96.1% (86.5%, 98.9%)

89.1% (72.1%, 96.3%)

28.9% (8.5%, 64%)

67.20%

80

20

84.7% (62.7%, 94.8%)

64.8% (37.6%, 84.9%)

8.4% (2.4%, 25.8%)

76.30%

30

96% (89.2%, 98.6%)

89% (77.1%, 95.1%)

28.7% (11.8%, 54.6%)

67.30%

40

99.1% (95.8%, 99.8%)

97.2% (90.5%, 99.2%)

63.8% (29.6%, 88.1%)

35.30%

85

20

96% (86.3%, 98.9%)

88.9% (70.3%, 96.4%)

28.4% (10.5%, 57.4%)

67.60%

30

99.1% (96.5%, 99.7%)

97.2% (92.1%, 99.1%)

63.6% (37.5%, 83.5%)

35.50%

40

99.8% (98.7%, 100%)

99.4% (97%, 99.9%)

88.4% (63.4%, 97.1%)

11.40%

90

20

99% (95.6%, 99.8%)

97.2% (89.4%, 99.3%)

63.3% (33.8%, 85.4%)

35.70%

30

99.8% (98.9%, 100%)

99.3% (97.4%, 99.8%)

88.3% (70.3%, 96%)

11.50%

40

100% (99.6%, 100%)

99.8% (99.1%, 100%)

97.1% (86.7%, 99.4%)

2.90%

95

20

99.8% (98.6%, 100%)

99.3% (96.6%, 99.9%)

88.2% (66.6%, 96.6%)

11.60%

30

99.9% (99.6%, 100%)

99.8% (99.2%, 100%)

97% (89.5%, 99.2%)

2.90%

40

100% (99.9%, 100%)

100% (99.7%, 100%)

99.3% (95.9%, 99.9%)

0.70%

100

20

99.9% (99.6%, 100%)

99.8% (98.9%, 100%)

97% (87.8%, 99.3%)

2.90%

30

100% (99.9%, 100%)

100% (99.7%, 100%)

99.3% (96.6%, 99.9%)

0.70%

40

100% (100%, 100%)

100% (99.9%, 100%)

99.8% (98.7%, 100%)

0.20%

105

20

100% (99.9%, 100%)

100% (99.7%, 100%)

99.3% (96.1%, 99.9%)

0.70%

30

100% (100%, 100%)

100% (99.9%, 100%)

99.8% (98.9%, 100%)

0.20%

40

100% (100%, 100%)

100% (100%, 100%)

100% (99.6%, 100%)

0%

110

20

100% (100%, 100%)

100% (99.9%, 100%)

99.8% (98.8%, 100%)

0.20%

30

100% (100%, 100%)

100% (100%, 100%)

100% (99.7%, 100%)

0%

40

100% (100%, 100%)

100% (100%, 100%)

100% (99.9%, 100%)

0%

115

20

100% (100%, 100%)

100% (100%, 100%)

100% (99.6%, 100%)

0%

30

100% (100%, 100%)

100% (100%, 100%)

100% (99.9%, 100%)

0%

40

100% (100%, 100%)

100% (100%, 100%)

100% (100%, 100%)

0%

120

20

100% (100%, 100%)

100% (100%, 100%)

100% (99.9%, 100%)

0%

30

100% (100%, 100%)

100% (100%, 100%)

100% (100%, 100%)

0%

40

100% (100%, 100%)

100% (100%, 100%)

100% (100%, 100%)

0%