AGG interruptions and maternal age affect FMR1 CGG repeat allele stability during transmission

Table 2 Mixed effects linear regression analysis of magnitude of expansion

Covariate	Parameter estimate^a	95% CI for parameter estimate	P value
Total CGG length	1.3	(1.0, 1.6)	<0.001
AGG (1 vs. 0 interruptions)	-9.8	(-18.8, -0.9)	0.031
AGG (2 or 3 vs. 0 interruptions)	-15.2	(-23.5, -6.8)	0.001
AGG (2 or 3 vs. 1 interruptions	-5.3	(-12.4, 1.8)	0.142
Parent age	0	(-0.4, 0.5)	0.919

^aIncremental change in magnitude of expansion for each unit increase in a continuous covariate, or difference in magnitude of expansion between levels of a categorical covariate.

ISSN: 1866-1955