Table 3 PIF ranking and effect on neurotrophic genes expression in FTDC
Amyloid processing 8.33E - 02 | Amyotrophic lateral sclerosis signaling 8.33E - 02 | Huntington’s disease signaling 7.69E - 02 | Synaptic long-term depression 6.45E - 02 | Axonal guidance signaling 5.75E - 02 | Neurotrophin/TRK signaling 4.00E - 02 | Neuregulin signaling 1.16E - 01 | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
AKT3 | 2.1 | GRIK2 | 2.5 | BDNF | 3 | GNA12 | -2 | ARHGEF12 | 9 | BDNF | 3 | NRG1 | 5 |
CDK5R1 | 2 | RAC1 | -2.4 | AKT3 | 2.1 | PPP2R1B | -2.5 | EPHA5 | 7.8 | CSNK2A1 | -2.3 | PLCG2 | 3.1 |
CSNK2A1 | -2.3 | SLC1A2 | -3 | EGF | 2.1 | GUCY1A3 | -4.9 | GLI2 | 6.1 | EGF | 2.1 | ||
PPP3CA | -9.2 | POLR2J2 | 2 | PPP2R2C | -6.5 | NRP1 | 4.2 | AKT3 | 2.1 | ||||
BCL2 | -27 | CDK5R1 | 2 | BDNF | 3 | CDK5R1 | 2 | ||||||
TCERG1 | -2 | RAP1A | 2.2 | ADAM17 | -2 | ||||||||
SNCA | -2 | AKT3 | 2.1 | PDK1 | -5.2 | ||||||||
CLTC | 3.1 | EGF | 2.1 | EGFR | -24.5 | ||||||||
RPH3A | -3.1 | DOCK1 | 2.1 | ||||||||||
EGFR | -24.5 | SEMA6D | 2.1 | ||||||||||
SLIT1 | 2.1 | ||||||||||||
RAC1 | -2.4 | ||||||||||||
ROBO1 | -2.5 | ||||||||||||
DPYSL5 | -4.6 | ||||||||||||
| Â | Â | Â | Â | Â | Â | Â | Â | PPP3CA | -9.2 | Â | Â | Â | Â |