Neonatal exposure to permethrin pesticide causes lifelong fear and spatial learning deficits and alters hippocampal morphology of synapses

Table 2 The synaptic numeric density, the surface density, the average area (S) and the percentage of perforated synapses (% PS) were calculated in the stratum moleculare of CA1 (SMCA1), mossy fibers (MF) and inner molecular layer of the dentate gyrus (IMLDG) of the hippocampus in control and permethrin (PERM)-treated groups

Area	Group	Nv^a(N. syn/μm³)	Sv^b(μm²/μm³)	S (μm²)	% PS
SMCA1	Control	1.847 ± 0.062	0.112 ± 0.002	0.092 ± 0.007	3.758 ± 0.462
SMCA1	PERM	1.504 ± 0.039^***	0.090 ± 0.004^**	0.088 ± 0.005	2.223 ± 0.308^*
MF	Control	2.431 ± 0.067	0.105 ± 0.003	0.064 ± 0.002	1.393 ± 0.137
MF	PERM	1.573 ± 0.049^***	0.081 ± 0.003^***	0.077 ± 0.002^**	1.453 ± 0.155
IMLDG	Control	2.240 ± 0.085	0.098 ± 0.003	0.065 ± 0.002	2.647 ± 0.195
	PERM	1.949 ± 0.028^**	0.081 ± 0.001^***	0.063 ± 0.001	1.911 ± 0.207^*

Group sizes: control (N = 6), PERM (N = 6). ***P <0.001 versus control group; **P < 0.01 versus control group; *P <0.05 versus control group. ^aNv, number of synapses/μm³ of tissue; ^bSv, overall area of synaptic junctional zones/μm³ of tissue.

ISSN: 1866-1955