From: There is variability in the attainment of developmental milestones in the CDKL5 disorder
 | Age at completion of questionnaire | |||||||
---|---|---|---|---|---|---|---|---|
1.5 years and under | 1.5–7 years | 7–13 years | 13 years and over | |||||
Developmental skill | Females (n = 11) | Males (n = 1) | Females (n = 50) | Males (n = 10) | Females (n = 32) | Males (n = 5) | Females (n = 16) | Males (n = 2) |
Gross motor | Â | |||||||
Roll front to back | 4 (36.4) | 1 (100) | 46 (92) | 5 (50) | 27 (84) | 2 (40) | 14 (88) | 1 (50) |
Roll back to front | 5 (45) | 1 (100) | 47 (94) | 5 (50) | 26 (81) | 2 (40) | 14 (88) | 1 (50) |
Transition from sitting to crawling position | 1 (9) | 1 (100) | 23 (46) | 3 (30) | 16 (50) | 0 (0) | 5 (31) | 1 (50) |
Crawl | 1 (9) | 0 (0) | 12 (24) | 2 (20) | 10 (31) | 0 (0) | 4 (25) | 1 (50) |
Stand with support | 2 (18) | 1 (100) | 37 (74) | 3 (30) | 22 (69) | 1 (20) | 10 (63) | 1 (50) |
Pull to stand | 1 (9) | 0 (0) | 13 (26) | 2 (20) | 14 (44) | 1 (20) | 6 (38) | 1 (50) |
Walk with support | 1 (9) | 0 (0) | 24 (48) | 1 (10) | 16 (50) | 1 (20) | 8 (50) | 1 (50) |
Fine motor | Â | |||||||
Transfer from hand to hand | 3 (27) | 1 (100) | 25 (50) | 2 (20) | 18 (56) | 0 (0) | 8 (50) | 0 (0) |
Play with blocks | 0 (0) | 0 (0) | 8 (16) | 1 (10) | 8 (25) | 0 (0) | 2 (13) | 0 (0) |
Social and communication | Â | |||||||
Social smile | 8 (73) | 1 (100) | 38 (76) | 7 (70) | 18 (56) | 1 (20) | 9 (56) | 0 (0)a |
Fix and follow | 3 (30.0)a | 1 (100) | 39 (78) | 4 (40) | 23 (72) | 1 (20) | 10 (67)a | 1 (100)a |
Wave goodbye | 0 (0.0) | 0 (0) | 11 (22) | 1 (10) | 4 (13) | 0 (0) | 1 (6) | 0 (0) |
Respond to own name | 4 (36) | 1 (100) | 33 (66) | 3 (33.3)a | 20 (63) | 2 (40) | 9 (56) | 0 (0) |
Point to things that he/she wants | 0 (0.0) | 0 (0) | 6 (12) | 1 (10) | 8 (26)a | 0 (0) | 2 (13) | 0 (0) |
Respond to others emotions | 4 (36) | 1 (100) | 23 (47)a | 4 (40) | 11 (34) | 1 (20) | 4 (25) | 1 (50) |
Respond to ‘no’ | 2 (18) | 0 (0) | 16 (32) | 2 (25)a | 13 (41) | 0 (0) | 4 (25) | 0 (0) |
Phrases | 0 (0.0) | 0 (0) | 3 (6) | 0 (0) | 3 (9) | 0 (0) | 1 (6) | 0 (0) |