Cerebral volumetric abnormalities in Neurofibromatosis type 1: associations with parent ratings of social and attention problems, executive dysfunction, and autistic mannerisms

Table 2 Cortical, subcortical, and white matter volumes of NF1 patients and healthy controls (HC)

	Group	Mean	SD	p ^a	p ^b
Gray matter volume (unnormalised)	HC	0.743621	0.091577	.180	.348
Gray matter volume (unnormalised)	NF1	0.796610	0.077320	.180	.348
White matter volume (unnormalised)	HC	0.582686	0.092045	.021	.041
White matter volume (unnormalised)	NF1	0.658080	0.082992	.021	.041
Thalamus left	HC	8168.40	814.18	<.001*	<.001*
	NF1	9584.09	737.11	<.001*	<.001*
Thalamus right	HC	7971.48	824.47	<.001*	<.001*
	NF1	9531.54	812.25	<.001*	<.001*
Putamen left	HC	5306.29	687.22	.003*	.036
	NF1	6108.28	734.30	.003*	.036
Putamen right	HC	5342.43	724.24	.005*	.058
	NF1	6170.75	754.84	.005*	.058
Pallidum left	HC	1855.57	200.37	<.001*	.001*
	NF1	2225.89	274.55	<.001*	.001*
Pallidum right	HC	1862.97	212.24	<.001*	.002*
	NF1	2251.49	301.51	<.001*	.002*
Hippocampus left	HC	3845.07	568.18	.002*	.029
	NF1	4521.35	559.96	.002*	.029
Hippocampus right	HC	3926.33	632.01	<.001*	<.001*
	NF1	4907.53	446.63	<.001*	<.001*
Caudate left	HC	3976.20	549.63	.044*	.341
	NF1	4465.80	674.85	.044*	.341
Caudate right	HC	4040.20	585.68	.005*	.062
	NF1	4780.13	722.43	.005*	.062
Amygdala left	HC	1102.04	195.87	.008*	.045
	NF1	1310.69	325.96	.008*	.045
Amygdala right	HC	1010.01	233.10	.030*	.135
	NF1	1216.24	393.13	.030*	.135
Accumbens left	HC	491.99	115.71	.018*	.068
	NF1	610.17	135.48	.018*	.068
Accumbens right	HC	326.92	79.81	.010*	.008*
	NF1	435.06	142.33	.010*	.008*

ISSN: 1866-1955