Fig. 1
From: Wnt signaling networks in autism spectrum disorder and intellectual disability
Summary of genetic and pharmacological evidence implicating Wnt signaling in developmental cognitive disorders. This diagram depicts the canonical Wnt signaling pathway which consists of Wnt binding to the Frizzled-LRP5/6 co-receptor complex and inhibiting the disassembly of the destruction complex which results in stabilized β-catenin levels, translocation to the nucleus, and initiation of Wnt-dependent gene transcription. Several genes in the canonical Wnt pathway are also identified as high-risk genes associated with autism and intellectual disability (CHD8, DDX3X, and TCF4). Furthermore, listed are a number of pharmacological agents and drugs that target Wnt signaling molecules and can modulate the pathway. Many of the genes listed are shared between different upstream ligand-receptor pathways