From: Functional characterization of rare FOXP2 variants in neurodevelopmental disorder
Varianta | Localization | Transcriptional repression | Dimerization with FOXPs | Interaction with CTBPs | Role in disorderb | ||||
---|---|---|---|---|---|---|---|---|---|
 |  | SV40 | SRPX2 | FOXP2 | FOXP1 | FOXP4 | CTBP1 | CTBP2 |  |
p.Q17L | + | + | + | + | + | + | + | + | Incidental |
p.M406T | + | + | + | + | + | + | + | + | Incidental |
p.P416T | + | + | + | + | + | + | + | + | Incidental |
p.R553H | − | − | − | − | − | − | − | − | Causal |
p.N597H | + | + | + | + | + | + | + | + | Incidental |
p.R328* | − | − | − | − | − | − | − | − | Causal |
P.Q390Vfs*7 | − | − | − | − | − | − | − | − | Causal |