Table 1 Summary of baseline control-treated KO and WT effects and KO acamprosate treatment effects

Increased UP state duration^*

Decreased UP state duration^*

Increased seizure severity score^*

No treatment effect on seizure severity score

Increased pERK/ERK total ratio HIP^*, STR^* lysate

Decreased pERK/ERK total ratio HIP^*, STR^* lysate

Increased pERK1/2+ cell counts^†

Decreased pERK1/2+ cell counts^*

Increased EZM time in open^*

Increased EZM time in open^*

Increased locomotor activity^*

Decreased locomotor activity^*