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Fig. 5 | Journal of Neurodevelopmental Disorders

Fig. 5

From: Delta rhythmicity is a reliable EEG biomarker in Angelman syndrome: a parallel mouse and human analysis

Fig. 5

Delta phenotypes are stronger at earlier ages in children with Angelman syndrome. a Increased occipital delta power in children with AS is age-dependent during wakefulness (NT: n = 54, AS: n = 26). b Occipital delta dynamics as a function of age in neurotypical and AS children. Longitudinal studies in a subset of AS patients show that c delta power and d delta dynamics decrease as a function of age (n = 12 children, n = 31 sessions). e Delta power during sleep (NT: n = 54, AS: n = 13) and f delta dynamics during sleep do not show statistical age dependence. g, h Analysis of grouped cross-sectional and longitudinal occipital delta power and dynamics during wakefulness and sleep. g Delta power during wakefulness was increased in AS at ages 4–6, 6–8, and 8+ (two-way ANOVA and post hoc Bonferroni: ***p < 0.0001, **p = 0.0002). Delta dynamics (IQR) during wakefulness were increased in AS at ages 4–6, 6–8, and 8+ (***p < 0.0001, **p = 0.0007). Sample sizes are represented in bars. h Delta power and dynamics during sleep were increased in AS at ages 4–6 and 6–8 (***p < 0.0001)

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