Table 5 Multinomial logistic regression analysis of the associations between frequency of breathing irregularities and age and mutation type

 0–6 years

REF

REF

REF

REF

 7–12 years

1.94 (0.71, 5.30)

0.20

1.39 (0.63, 3.03)

0.41

1.13 (0.36, 3.54)

0.83

0.32 (0.15, 0.69)

<0.01

 13–19 years

0.90 (0.31, 2.55)

0.84

1.05 (0.49, 2.28)

0.90

1.74 (0.57, 5.26)

0.33

0.19 (0.08, 0.45)

<0.01

 20 years and above

1.51 (0.55, 4.13)

0.42

0.56 (0.25, 1.27)

0.17

2.33 (0.77, 7.08)

0.14

0.19 (0.08, 0.46)

<0.01

 C-terminal deletion

REF

REF

REF

REF

 Early truncating

2.35 (0.52, 10.65)

0.27

2.15 (0.63, 7.33)

0.22

1.79 (0.38, 8.37)

0.46

1.26 (0.42, 3.79)

0.68

 Large deletion

2.49 (0.57, 10.96)

0.23

1.57 (0.45, 5.45)

0.48

3.02 (0.72, 12.69)

0.13

0.74 (0.22, 2.47)

0.63

 p.Arg106Trp

1.96 (0.41, 9.33)

0.40

0.71 (0.17, 2.99)

0.64

2.82 (0.56, 14.10)

0.21

0.77 (0.17, 3.52)

0.73

 p.Arg133Cys

1.07 (0.27, 4.25)

0.92

0.76 (0.26, 2.25)

0.62

3.07 (0.76, 12.38)

0.12

1.04 (0.34, 3.15)

0.95

 p.Arg168*

1.35 (0.39, 4.67)

0.64

0.76 (0.27, 2.09)

0.59

2.90 (0.80, 10.51)

0.11

0.47 (0.16, 1.41)

0.18

 p.Arg255*

0.81 (0.20, 3.28)

0.77

1.43 (0.53, 3.81)

0.48

2.00 (0.51, 7.80)

0.32

1.20 (0.46, 3.16)

0.71

 p.Arg270*

1.85 (0.45, 7.54)

0.39

0.99 (0.30, 3.33)

0.99

1.84 (0.39, 8.68)

0.44

0.89 (0.27, 2.90)

0.84

 p.Arg294*

1.10 (0.26, 4.64)

0.90

0.91 (0.30, 2.77)

0.87

0.780 (0.13, 4.92)

0.81

1.35 (0.46, 3.94)

0.58

 p.Arg306Cys

1.16 (0.27, 4.98)

0.85

0.93 (0.30, 2.88)

0.90

3.15 (0.70, 14.18)

0.14

1.46 (0.47, 4.48)

0.51

 p.Thr158Met

1.30 (0.34, 4.95)

0.70

1.07 (0.37, 3.06)

0.90

3.23 (0.85, 12.27)

0.08

0.86 (0.29, 2.51)

0.78

 Other mutations

0.96 (0.28, 3.26)

0.94

0.49 (0.18, 1.30)

0.15

3.20 (0.92, 11.18)

0.07

0.19 (0.05, 0.71)

0.01