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Fig. 4 | Journal of Neurodevelopmental Disorders

Fig. 4

From: A randomized double-blind, placebo-controlled trial of ganaxolone in children and adolescents with fragile X syndrome

Fig. 4

Post hoc analyses of primary and secondary measures. Post hoc analysis in subpopulations of children with FXS. Difference at end of treatment periods, adjusted for baseline (square), and 95% confidence interval (line). Positive scores on the VAS indicate improvement. For all other measures, negative scores indicate improvement. No subgroups showed statistically significant effects on primary or key secondary measures. Participants with higher baseline anxiety (a) showed positive effects across multiple test measures in areas of anxiety (VAS and ADAMS) and hyperactivity (ADAMS and ABC-CFX). Participants with low FSIQ (b) showed positive effects across the most behavior areas. Participants with ASD (c) and young participants (d) showed the modest effects on secondary measures. Only measures with p value <0.1 displayed for other secondary outcomes. ADHD attention-deficit hyperactivity disorder, VAS Visual Analogue Scale, SNAP IV Swanson, Nolan, and Pelham-IV Questionnaire, PARS Pediatric Anxiety Rating Scale, ADAMS Anxiety, Depression and Mood Scale, CGI-I Clinical Global Impression-Improvement, ABC-C Aberrant Behavior Checklist-Community Edition FXS algorithm (ABC-CFX)

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