Load matters: neural correlates of verbal working memory in children with autism spectrum disorder

Table 4 Regions of significant differences between TD and ASD groups

Voxels	MNI coordinates			Z value	p value	Hem.	Region
Voxels	x	y	z	Z value	p value	Hem.	Region
1341	− 10	40	26	3.38	3.37 × 10⁻⁴	L	Medial frontal gyrus
x	− 14	8	50	3.32		L	Cingulate gyrus
x	− 16	6	62	3.26		L	Superior frontal gyrus
1175	38	− 36	44	3.58	9.25 × 10⁻⁴	R	Inferior parietal lobule
1095	14	− 52	46	3.7	1.53 × 10⁻³	R	Precuneus
x	− 6	− 62	52	3.32		L	Precuneus
833	54	36	22	3.73	8.73 × 10⁻³	R	Middle frontal gyrus
x	28	42	38	3.16		R	Superior frontal gyrus

Results from between group comparisons of the linear trend analyses from D3 to D6. All regions reported are areas where TD children showed greater positive linear relations between cortical activity and difficulty level (increasing BOLD signal with increasing task difficulty) than children with ASD. There were no areas where children with ASD showed greater linear relations between cortical activity and difficulty level than TD children. MNI coordinates represent the peak Z values of the cluster; X peak local maximas within cluster

ISSN: 1866-1955