Differentiating social preference and social anxiety phenotypes in fragile X syndrome using an eye gaze analysis: a pilot study

Table 1 Clinical characterization

	FXS	TDC	ASD
N	17	17	17
Age	16.6 ± 6.1	16.6 ± 5.8	16.5 ± 5.8
Gender (% male)	70.6	70.6	70.6
ASD (% clinically diagnosed)	17.6	0	100
IQ	58.6 ± 17.7^ac	102.4 ± 12.3^b	95.9 ± 29.8^b
VABS-II Communication subscale	58.1 ± 18.2
VABS-II Daily Living subscale	65.4 ± 10.8
VABS-II Socialization subscale	64.7 ± 9.6
VABS-II Adaptive Behavior Composite	61.2 ± 12.0
SCQ	13.0 ± 7.7^a	1.8 ± 1.9^b
ADAMS Manic/Hyperactivity subscale	7.0 ± 4.2^a	0.8 ± 1.4^b
ADAMS Depressed Mood subscale	2.8 ± 3.5^a	0.8 ± 1.4^b
ADAMS Social Anxiety subscale	7.2 ± 5.5^a	1.1 ± 2.4^b
ADAMS Generalized Anxiety subscale	8.1 ± 5.7^a	1.2 ± 1.8^b
ADAMS Compulsive Behavior subscale	2.1 ± 2.2^a	0.2 ± 0.8^b
ABC-C Irritability	13.7 ± 14.1^a	0.4 ± 1.0^bc	12.4 ± 12.1^a
ABC-C Lethargy	5.3 ± 5.4^a	0.5 ± 1.7^bc	8.8 ± 7.9^a
ABC-C Stereotypy	2.7 ± 3.5^a	0.0 ± 0.0^bc	3.6 ± 3.6^a
ABC-C Hyperactivity	8.5 ± 6.6^a	0.5 ± 0.9^bc	7.5 ± 5.2^a
ABC-C Inappropriate Speech	4.5 ± 3.7^a	0.1 ± 0.3^bc	3.5 ± 2.8^a
ABC-C Social Avoidance	3.3 ± 3.1^a	0.5 ± 1.5^bc	5.2 ± 4.4^a

Descriptive statistics reported as means ± standard deviation
FXS fragile X syndrome, TDC typically developing control, ASD idiopathic autism spectrum disorder, VABS-II Vineland Adaptive Behavior Scales II, SCQ Social Communication Questionnaire, ADAMS Anxiety, Depression, and Mood Scale, ABC-C Aberrant Behavior Checklist - Community
^aStatistically different from TDC (ANOVA followed by post hoc testing or independent samples t test)
^bStatistically different from FXS (ANOVA followed by post hoc testing or independent samples t test)
^cStatistically different from ASD (ANOVA followed by post hoc testing or independent samples t test)

ISSN: 1866-1955