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Table 1 Clinical characterization

From: Differentiating social preference and social anxiety phenotypes in fragile X syndrome using an eye gaze analysis: a pilot study

  FXS TDC ASD
N 17 17 17
Age 16.6 ± 6.1 16.6 ± 5.8 16.5 ± 5.8
Gender (% male) 70.6 70.6 70.6
ASD (% clinically diagnosed) 17.6 0 100
IQ 58.6 ± 17.7ac 102.4 ± 12.3b 95.9 ± 29.8b
VABS-II Communication subscale 58.1 ± 18.2   
VABS-II Daily Living subscale 65.4 ± 10.8   
VABS-II Socialization subscale 64.7 ± 9.6   
VABS-II Adaptive Behavior Composite 61.2 ± 12.0   
SCQ 13.0 ± 7.7a 1.8 ± 1.9b  
ADAMS Manic/Hyperactivity subscale 7.0 ± 4.2a 0.8 ± 1.4b  
ADAMS Depressed Mood subscale 2.8 ± 3.5a 0.8 ± 1.4b  
ADAMS Social Anxiety subscale 7.2 ± 5.5a 1.1 ± 2.4b  
ADAMS Generalized Anxiety subscale 8.1 ± 5.7a 1.2 ± 1.8b  
ADAMS Compulsive Behavior subscale 2.1 ± 2.2a 0.2 ± 0.8b  
ABC-C Irritability 13.7 ± 14.1a 0.4 ± 1.0bc 12.4 ± 12.1a
ABC-C Lethargy 5.3 ± 5.4a 0.5 ± 1.7bc 8.8 ± 7.9a
ABC-C Stereotypy 2.7 ± 3.5a 0.0 ± 0.0bc 3.6 ± 3.6a
ABC-C Hyperactivity 8.5 ± 6.6a 0.5 ± 0.9bc 7.5 ± 5.2a
ABC-C Inappropriate Speech 4.5 ± 3.7a 0.1 ± 0.3bc 3.5 ± 2.8a
ABC-C Social Avoidance 3.3 ± 3.1a 0.5 ± 1.5bc 5.2 ± 4.4a
  1. Descriptive statistics reported as means ± standard deviation
  2. FXS fragile X syndrome, TDC typically developing control, ASD idiopathic autism spectrum disorder, VABS-II Vineland Adaptive Behavior Scales II, SCQ Social Communication Questionnaire, ADAMS Anxiety, Depression, and Mood Scale, ABC-C Aberrant Behavior Checklist - Community
  3. aStatistically different from TDC (ANOVA followed by post hoc testing or independent samples t test)
  4. bStatistically different from FXS (ANOVA followed by post hoc testing or independent samples t test)
  5. cStatistically different from ASD (ANOVA followed by post hoc testing or independent samples t test)