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Table 2 Differences in gait parameters between proband children with 16p11.2 and their unaffected siblings

From: Quantitative gait assessment in children with 16p11.2 syndrome

Variable Genetic variant Unaffected siblings
Timed-up-and-go test (sec) 4.81 (1.4) 4.19 (1.3)*
10-m walk/run test (sec) 3.52 (1.0) 2.91 (0.7)*
6-min walk test (meters) 429 (72.5) 496 (201.3)
6-min walk test (% predicted) 71.6 (11.6) 88 (11.1)***
Preferred-pace walking
 Velocity (cm/sec) 114.5 (18.4) 130.4 (31.6)
 Stride length (cm) 112.5 (24.0) 110.6 (49.2)
 Base of support (cm) 10.3 (4.7) 6.9 (2.4)**
 Double support time (%) 22.9 (6.1) 20.0 (4.7)
Fast-pace walking
 Velocity (cm/sec) 198.8 (50.1) 192.7 (55.0)
 Stride length (cm) 133.8 (36.0) 127.7 (65.6)
 Base of support (cm) 10.0 (5.1) 6.7 (2.4)*
 Double support time (%) 14.9 (5.6) 11.9 (7.2)
  1. Significant differences in gait parameters between children with and without genetic variant 16p.11.2. Descriptive values are medians (interquartile range)
  2. Abbreviations: m meter, min minute, cm centimeters, sec seconds
  3. p < 0.05 (*), p < 0.01 (**), p < 0.001(***)