Table 2 Differences in gait parameters between proband children with 16p11.2 and their unaffected siblings
From: Quantitative gait assessment in children with 16p11.2 syndrome
Variable | Genetic variant | Unaffected siblings |
|---|---|---|
Timed-up-and-go test (sec) | 4.81 (1.4) | 4.19 (1.3)* |
10-m walk/run test (sec) | 3.52 (1.0) | 2.91 (0.7)* |
6-min walk test (meters) | 429 (72.5) | 496 (201.3) |
6-min walk test (% predicted) | 71.6 (11.6) | 88 (11.1)*** |
Preferred-pace walking | ||
 Velocity (cm/sec) | 114.5 (18.4) | 130.4 (31.6) |
 Stride length (cm) | 112.5 (24.0) | 110.6 (49.2) |
 Base of support (cm) | 10.3 (4.7) | 6.9 (2.4)** |
 Double support time (%) | 22.9 (6.1) | 20.0 (4.7) |
Fast-pace walking | ||
 Velocity (cm/sec) | 198.8 (50.1) | 192.7 (55.0) |
 Stride length (cm) | 133.8 (36.0) | 127.7 (65.6) |
 Base of support (cm) | 10.0 (5.1) | 6.7 (2.4)* |
 Double support time (%) | 14.9 (5.6) | 11.9 (7.2) |