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Table 4 Comparison of males by allelic class on corrected intellectual functioning, ASD features and maladaptive behaviours

From: Intellectual functioning and behavioural features associated with mosaicism in fragile X syndrome

 

FM-only

PM/FM Mosaic

p

n

Mean ± SD

n

Mean ± SD

Intellectual functioning1

 cVIQ

69

41.5 ± 23.2

18

59.6 ± 19.7

0.032

 cPIQ

69

42.1 ± 20.3

19

54.1 ± 14.1

0.138

 cWMI

25

30.0 ± 11.4

9

51.7 ± 13.0

0.075

 cPSI

34

38.9 ± 11.6

12

62.8 ± 20.0

0.004*

 cFSIQ

69

28.9 ± 23.8

18

49.9 ± 18.1

0.019*

ASD features2

 ADOS CSS

64

6.67 ± 2.06

16

6.00 ± 2.31

0.930

 SA CSS

64

6.38 ± 2.26

16

5.69 ± 2.18

0.658

 RRB CSS

64

7.64 ± 1.92

16

7.31 ± 1.78

0.710

Maladaptive behaviours3

 Irritability

70

15.5 ± 11.4

20

9.00 ± 7.58

0.011*

 Lethargy

70

6.71 ± 5.42

20

4.65 ± 3.63

0.117

 Stereotypy

70

5.60 ± 4.66

20

3.90 ± 4.39

0.233

 Hyperactivity

70

12.1 ± 8.28

20

8.35 ± 7.63

0.071

 Inappropriate speech

70

4.90 ± 3.50

20

2.80 ± 3.27

0.009*

 Social avoidance

70

3.47 ± 2.75

20

2.05 ± 3.07

0.012*

 ABC total

70

48.3 ± 28.3

20

30.8 ± 23.4

0.012*

 ABC UI

70

0.62 ± 0.19

20

0.73 ± 0.16

0.006*

  1. 1Semi-parametric regression adjusted for country, age and ADOS CSS
  2. 2Robust regression adjusted for cFSIQ
  3. 3Robust regression adjusted for age
  4. *p value remained < 0.05 after adjustment for multiple testing using FDR