A diffusion-weighted imaging tract-based spatial statistics study of autism spectrum disorder in preschool-aged children

Table 2 Clusters with significant effect of group and group by sex interaction

Effect	Feature	Cluster ID	Tract(s)	p	t_max	voxels	X (mm)	Y (mm)	Z (mm)
Diagnosis	FA	1	R/L middle/superior cerebellar peduncle, corticospinal tract, cerebral peduncle, anterior/posterior internal capsule, L anterior/superior/posterior corona radiata, posterior thalamic radiation, external capsule, fornix, superior longitudinal fasciculus, superior, fronto-occipital fasciculus	0.013	4.57	5748	5	− 30	− 18
		2	R anterior/posterior internal capsule, superior/posterior corona radiata, posterior thalamic radiation, inferior longitudinal fasciculus, inferior frontal-occipital fasciculus, external capsule	0.026	4	1416	30	− 31	12
		3	Genu/body/splenium corpus callosum, R anterior/superior/posterior corona radiata	0.015	5.17	1037	17	2	33
		4	R inferior longitudinal fasciculus, inferior fronto-occipital fasciculus	0.038	4.02	399	36	− 34	− 18
		5	R anterior corona radiata	0.045	3.7	79	38	37	6
		6	R anterior corona radiata	0.048	3.35	48	19	29	− 5
		7	R anterior limb internal capsule	0.047	3.66	28	16	10	9
		8	R forceps major, posterior corona radiata	0.05	3.29	6	35	− 63	19
Diagnosis-by-sex	AD	1	Genu/body corpus callosum, R anterior/superior corona radiata	0.036	3.61	532	16	2	32
		2	R anterior/superior corona radiata, external capsule	0.04	3.51	445	25	28	19
		3	Body/splenium corpus callosum, R posterior corona radiata	0.038	4.14	263	16	− 26	30
		4	Genu/body corpus callosum	0.042	3.39	229	1	12	20
		5	R anterior corona radiata	0.047	2.96	80	30	18	30
		6	Body corpus callosum	0.045	3.57	45	− 1	− 4	24

Note: Clusters of significant group differences (ASD > TD) and diagnosis-by-sex interaction effects. Fractional anisotropy (FA), axial diffusivity (AD), tracts identified according to the MRI Atlas of Human White Matter [77], L (left), R (right), p indicates the threshold-free cluster enhancement-corrected p value for the cluster, t_max indicates maximum t statistic within the cluster at X Y Z MNI coordinates in millimeters

ISSN: 1866-1955