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Fig. 3 | Journal of Neurodevelopmental Disorders

Fig. 3

From: Functional characterization of rare NRXN1 variants identified in autism spectrum disorders and schizophrenia

Fig. 3

3D structure of NRXN1α (PDB ID: 3r05) with a modeled loop with N-glycan. a 3D structure of NRXN1α by ribbon representation. b Enlarged view around the LNS4 domain. The three mutated sites (T737, D772, and R856) are indicated by red dotted circles. The potential glycosylation site N790 is enhanced by the blue dotted circle. The model structure for loop 789–792 is indicated by white color. A model structure of complex-type N-glycan is indicated by pink color; this structure is one of the two conformations that contact both D772 and R856 among 300 candidate conformations

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