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Table 2 Litter effect reflected in E15.5 body and organ weights of wild-type and Chd8V986*/+ mutant mice

From: Controlling litter effects to enhance rigor and reproducibility with rodent models of neurodevelopmental disorders

  Standard analysis (litter effect ignored) Mixed-effects model
Brain:
 Sex 0.606 0.476
 Genotype 0.695 0.587
Variation in brain weights explain by litter effect: 53.4%
Body:
 Sex 0.829 0.696
 Genotype 0.032* 0.0003***
Variation in body weights explained by litter effect: 63.7%
Placenta:
 Sex 0.008** 0.001**
 Genotype 0.06# 0.023*
Variation in placenta weights explained by litter effect: 34.4%
  1. ***p < 0.001, **p < 0.01, *p < 0.05, #p < 0.1