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Table 2 Litter effect reflected in E15.5 body and organ weights of wild-type and Chd8V986*/+ mutant mice

From: Controlling litter effects to enhance rigor and reproducibility with rodent models of neurodevelopmental disorders

 

Standard analysis (litter effect ignored)

Mixed-effects model

Brain:

 Sex

0.606

0.476

 Genotype

0.695

0.587

Variation in brain weights explain by litter effect: 53.4%

Body:

 Sex

0.829

0.696

 Genotype

0.032*

0.0003***

Variation in body weights explained by litter effect: 63.7%

Placenta:

 Sex

0.008**

0.001**

 Genotype

0.06#

0.023*

Variation in placenta weights explained by litter effect: 34.4%

  1. ***p < 0.001, **p < 0.01, *p < 0.05, #p < 0.1
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Journal of Neurodevelopmental Disorders

ISSN: 1866-1955

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