Quantitative trait variation in ASD probands and toddler sibling outcomes at 24 months

Table 5 Linear regression analyses: MSEL examiner-based assessment

	Beta^a	95% CI lower	95% CI upper	p value
ELC model (n = 317)
Proband VABS-II ABC	0.30	0.09	0.50	0.004⁺
Sibling sex	− 0.29	− 0.49	− 0.10	0.003
Group	1.13	0.90	1.36	< 0.0001
Proband score x group	− 0.22	− 0.44	0.01	0.066
EL model (n = 324)
Proband VABS-II EL	0.34	0.14	0.55	< 0.0001⁺
Sibling sex	− 0.18	− 0.38	0.03	0.089
Group	0.80	0.57	1.04	< 0.0001
Proband score x group	− 0.18	− 0.42	0.05	0.122
RL model (n = 323)
Proband VABS-II RL	0.47	0.28	0.66	< 0.0001⁺
Sibling sex	− 0.14	− 0.33	0.05	0.140
Group	1.14	0.91	1.36	< 0.0001
Proband score x group	− 0.39	− 0.61	− 0.17	< 0.0001⁺

ELC Early Learning Composite, EL expressive language, RL receptive language
^aStandardized beta coefficients from linear regression models. Reference groups for sibling sex and group are female (vs. male) and HR-ASD (vs. HR-NoASD), respectively. Full model results are shown in Additional file 1: Table S5
⁺significant at p ≤ 0.008 after Bonferroni correction for main and interacting effects of proband score (6 comparisons)

ISSN: 1866-1955