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Table 1 Design of the experiment in adults

From: mTOR inhibitor improves autistic-like behaviors related to Tsc2 haploinsufficiency but not following developmental status epilepticus

Time points

Habituation

T1

Everolimus administration

Washing out period

T3

 

T2

Procedure

OF, EPM

Behavioral testing battery

 

Behavioral testing battery

 

Behavioral testing battery

Age

P74–P78

P81–P92

 

P95–P106

 

P158–P169

Duration

2 days

4 days

 

4 days

8 weeks

4 days

12 days, 6 injections (every other day)

  1. EPM elevated plus maze test, OF open field test, P postnatal day