Reflections on the genetics-first approach to advancements in molecular genetic and neurobiological research on neurodevelopmental disorders

Table 1 Gene–protein network involvement of 16 prevalent high-confidence NDD genes

Gene	*Wnt/β*-catenin	FMRP	CHD8	TBR1
ADNP		[7]	ST [20]^a	ST [23]
ARID1B	ST	[7]	ST [20]^a	[23]
ASH1L			ST
ASXL3			ST
CHD8	ST [14]	ST [7]	[20]	ST
DYRK1A	ST	ST	ST	ST [23]
FOXP1	ST		ST	ST
GRIN2B	ST	ST [7]	ST	ST [23]
MECP2		ST	ST	ST
POGZ			ST [20]^a	ST [23]
PTEN	ST [14]	ST	ST [20]
SCN2A		ST [7]	ST [20]	ST [23]
SHANK3			[20]
KMT5B			ST [20]^a
SYNGAP1		ST	ST [20]^a
WDFY3		[7]	ST

Note: Numbers indicate sources (see References) that report gene involvement in each category. ST, STRING [24] interaction score of at least 0.30 with the protein as the central node. ^aGene had CHD8 binding sites but fold change was not statistically significant, as reported in [20]. CHD2 was not included in the table as it was not involved in any of the reviewed protein pathways

ISSN: 1866-1955