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Table 1 Gene–protein network involvement of 16 prevalent high-confidence NDD genes

From: Reflections on the genetics-first approach to advancements in molecular genetic and neurobiological research on neurodevelopmental disorders

Gene Wnt/β-catenin FMRP CHD8 TBR1
ADNP   [7] ST [20]a ST [23]
ARID1B ST [7] ST [20]a [23]
ASH1L    ST  
ASXL3    ST  
CHD8 ST [14] ST [7] [20] ST
DYRK1A ST ST ST ST [23]
FOXP1 ST   ST ST
GRIN2B ST ST [7] ST ST [23]
MECP2   ST ST ST
POGZ    ST [20]a ST [23]
PTEN ST [14] ST ST [20]  
SCN2A   ST [7] ST [20] ST [23]
SHANK3    [20]  
KMT5B    ST [20]a  
SYNGAP1   ST ST [20]a  
WDFY3   [7] ST  
  1. Note: Numbers indicate sources (see References) that report gene involvement in each category. ST, STRING [24] interaction score of at least 0.30 with the protein as the central node. aGene had CHD8 binding sites but fold change was not statistically significant, as reported in [20]. CHD2 was not included in the table as it was not involved in any of the reviewed protein pathways