Genetic counseling as preventive intervention: toward individual specification of transgenerational autism risk

Table 1 Descriptions of analyses and study samples

Analysis	Study samples
	New analysis of existing data				New data
	Simons Simplex Collection		Autism Genetic Resource Exchange	WUSTL Family Studies	2nd Generation Project		WUSTL Genomic Sample
	Mothers	Fathers	Autism Genetic Resource Exchange	WUSTL Family Studies	Unaffected mothers	Offspring	WUSTL Genomic Sample
1a. Maternal QATs* in simplex versus multiplex families	N=2839		N=52	N=245
1b. Maternal QATs* in pedigrees consistent or not consistent with silent maternal transmission				N=88	N=8
*2. Parental QATs in simplex families with/without de novo variants in ASD-affected offspring**	N=2851	N=2851
*3. Maternal QATs for unaffected sisters of ASD-affected sibling with/without ASD-affected offspring**					N=41
4. Offspring ASD diagnosis for unaffected mothers with ASD-affected sibling					N=113	N=220
5. Maternally inherited variants in ASD-affected offspring with/without maternal family history of ASD							N=103
6a. Parental age in simplex families relative to number of de novo variants in ASD-affected offspring	N=2140	N=2140
6b. Parental age in simplex families relative to number of de novo variants in unaffected siblings of ASD-affected offspring	N=1605	N=1605

Study samples are listed according to whether they were derived from existing or new data collections. Rows list analyses based on their order in the text. Numbers of participants from each sample for a given analysis are listed by column headings. Bolded analyses were statistically significant (p<.05)
WUSTL Washington University in St. Louis, QATs Quantitative Autistic Traits
*All QATs were measured with the Social Responsiveness Scale-2 [29]

ISSN: 1866-1955