Table 2 Maternal QAT burden stratified by family transmission pattern
ASD risk category | N | Mean (SD) | Statistics | Effect size (95% CI) |
|---|---|---|---|---|
Analysis 1a. Maternal QATs in simplex versus multiplex families | ||||
 Simplex | 3029 | 46.17 (7.29) | t(3134)=−1.36; p=.18 | −0.13 (−0.33, 0.06) |
 Multiplex | 107 | 47.14 (7.48) |  |  |
Analysis 1b. Maternal QATs in pedigrees consistent or not consistent with silent maternal transmission | ||||
 Pedigree not consistent with silent maternal transmission | 73 | 46.63 (9.24) | t(94)=−1.06; p=.29 | −0.25 (−0.72, 0.22) |
 Pedigree consistent with silent maternal transmission | 23 | 48.96 (8.82) |  |  |
Analysis 2. Maternal QATs in simplex families with versus without de novo variant in ASD-affected offspring | ||||
 ASD-associated de novo variant | 323 | 45.08 (6.52) | t(428)=−3.04, p=.003 | −0.17 (−0.28, −0.05) |
 No ASD-associated variant | 2528 | 46.27 (7.23) |  |  |
Analysis 3. Maternal QATs for unaffected sisters with an ASD-affected sibling and offspring with or without ASD | ||||
 No offspring ASD | 33 | 41.33 (6.33) | t(31)=−2.20; p=.03 | −0.85 (−1.63, −0.07) |
 Established offspring ASD | 8 | 47.13 (8.06) |  |  |