Fig. 4

JZL-184 treatment improves inter-trial phase coherence to auditory chirp in Fmr1 KO mice 4 h post-treatment. Graphs show group mean differences between JZL-184-treated Fmr1 KO mice (N = 13) 4 h post-treatment compared with Fmr1 KO mice prior to treatment (N = 22) in left/right frontal, medial, and temporal regions of the mouse cortex. Monte Carlo statistical method on cluster analysis revealed a significant increase (p < 0.025) in average ITPC values in JZL-184-treated Fmr1 KO mice (yellow and red regions with dotted black outline) in the gamma-band range (~ 30–100 Hz) in all regions. Abbreviations: LF, left frontal; RF, right frontal; LM, left medial; RM, right medial; LT, left temporal; RT, right temporal