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Fig. 4 | Journal of Neurodevelopmental Disorders

Fig. 4

From: Comparison of SHANK3 deficiency in animal models: phenotypes, treatment strategies, and translational implications

Fig. 4

Phenotypes and effective compounds in the murine model ex4-22|ALL and SHANK3-deficient macaques. The phenotypes of the respective models are summarized according to the categories and interpretations, which were assigned to the performed experiments. On the y-axis the abnormality score (1 = normal; 2 = abnormal) is plotted per interpretation on the x-axis. Concentric circles are added around the circular barplot to illustrate the influence of a subset of treatment strategies on the phenotypes. Bold black lines indicate a full rescue of the observed deficits, while thinner grey lines indicate a partial normalization of the respective phenotype. Importantly, only beneficial effects were included in this visualization. The abbreviations used in this illustration are summarized in TableĀ 1

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