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Table 1 Categories used in the database and circular barplots. Every data point was assigned to a category, subcategory, and an interpretation

From: Comparison of SHANK3 deficiency in animal models: phenotypes, treatment strategies, and translational implications

Category

Subcategory

Interpretation

Shortcut

Structure

Molecular

Protein_composition

PROT_COMP

  

Protein_localization

PROT_LOC

  

Protein_interaction

PROT_INT

  

RNA_composition

RNA_COMP

  

Cytoskeleton

CYTSKEL

  

Epigenetics

EPIGEN

 

Physiology

Synaptic_transmission

SYN_TRANS

  

Synaptic_plasticity

SYN_PLST

  

Homeostatic_plasticity

HOM_PLST

  

Cellular_excitability

CELL_EXC

  

Signaling

SGNLNG

  

Translation

TRNSLTN

  

Functional_connectivity

CON_FUN

  

Induced_connectivity

CON_IND

  

Baseline_neuronal_activity

NEUACT_BAS

  

Induced_neuronal_activity

NEUACT_IND

  

Neuronal_encoding

NEU_ENC

  

Synaptic_maturation

SYN_MAT

  

Inflammation

INFLAM

  

Microbiome

MCRBM

  

GIT_permeability

GIT_PERM

 

Morphology

Region

CNS_REGION

  

Tracts

CNS_TRACT

  

Neuroanatomy

NEUANTMY

  

Spines

SPINE

  

Synapses

SYNAPSE

  

Dendrites

DENDR

  

PSD

PSD

  

Skeletal_muscle

SKEL_MUSC

  

GIT

GIT

Behavior

Social

Social_motivationinteraction

SOC_MOTINT

  

Social_recognition

SOC_REC

  

Social_communication

SOC_COM

 

Stereotypies

Repetitive_behavior

REP_BHVR

  

Perseverative_behavior

PERSVRTN

  

Restricted_interests

RSTR_INTRST

 

Other_behavior

Anxiety

ANXTY

  

Avoidance_behavior

AVD_BHVR

  

Aggression

AGGRSN

  

Escape_behavior

ESC_BHVR

  

Food_intake

FOOD_INT

  

Circadian_rhythm

CIRCDN

Neurology

Cognition

Spatial_learning

SPTL_LRN

  

Associative_learning

ASSO_LRN

  

Instrumental_learning

INSTR_LRN

  

Perceptual_learning

PRCPTL_LRN

  

Recognition_memory

REC_MEM

  

Attention

ATTN

 

Motor

Activity

ACT

  

Neuromuscular

NRMUSC

  

Sensorimotor

SENSMOT

  

Motor_learning

MOT_LRN

  

Motor_general

MOT_GEN

 

Sensory

Somatosensory

SOMSENS

  

Sensorimotor_gating

SENSMOT_GT

  

Olfaction

OLF

  

Vision

VIS

  

Audition

AUD

  

Vestibular

VEST

 

Other_neurology

Seizures

SEIZRS

  

Sleep

SLEEP