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Table 6 Comparison of profiles by sex, age, impact, and seizure frequency

From: Symptom rates and profile clustering in tuberous sclerosis complex-associated neuropsychiatric disorders (TAND)

 

Profile 1

(N = 127)

Profile 2

(N = 58)

Profile 3

(N = 64)

Profile 4

(N = 63)

Profile 5

(N = 69)

Profile 6

(N = 63)

Profile 7

(N = 198)

Totala

(N = 642)

Sex (percent male)b

62%

50%

64%

46%

42%

57%

44%

52%

2 = 17.9, df 6, p = 0.006)

(5,7)*

--

(7)*

--

(1)*

--

(1,3)*

Age (average, SD)b

16.5

(±11.0)

21.4

(±15.5)

16.2 (±10.7)

17.5

(± 9.6)

23.8 (±15.4)

13.3

(±13.7)

14.1

(±16.5)

16.7 (± 14.2)

(F6,635 = 5.93, p < 0.0001)

(5)**

(6,7)*

(5)**

(5)*

(6,7)***

(1,3)**

(4)*

(5)***

(2)*

(5)***

(2)*

Impact (average, SD)b

7.1

(±2.4)

n = 125

5.9

(±2.8)

5.6

(±2.2)

4.2

(±2.5)

n = 62

5.3

(±2.6)

n = 66

4.6

(±2.6)

2.47

(±2.9)

n = 195

4.69 (± 3.2)

(F6,626 = 44.81, p < 0.0001)

(3,4,5,6,7)***

(2)**

(4,7)***

(1)**

(6)*

(1,7)***

(4)**

(6)*

(1,2,7)***

(3)**

(5)*

(1,7)***

(4)*

(1,7)***

(2,3)*

(1,2,3,4,5,6)***

Monthly seizure frequency (average, SD)b

47.3 (±133.4)

n = 122

35.5

(±92.7)

n = 56

37.4 (±95.0)

n = 63

5.0

(±15.8)

n = 62

11.3 (±32.4)

n = 66

58.8

(±98.9)

25.8

(±81.4)

n = 195

31.7 (± 93.12)

(F6,620 = 3.08, p = 0.006)

(4)**

(5)*

--

(4)*

(1,6,7)**

(3)*

(6)**

(1)*

(4,5)**

(4)**

  1. *p < 0.05, **p < 0.01, ***p < 0.001 (FDR-adjusted)
  2. aChi-square test for sex, one-way ANOVA for age, impact, and monthly seizure Frequency
  3. bSample size specified if different from profile size