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Table 3 The seven natural TAND clusters and their items

From: The research landscape of tuberous sclerosis complex–associated neuropsychiatric disorders (TAND)—a comprehensive scoping review

TAND clusters

TAND items

1. Scholastic

Reading, writing, spelling, mathematics

2. Neuropsychological

Memory, disorientation, attention deficits (behavioural and neuropsychological), visuo-spatial deficits, dual-task deficits, executive function deficits

3. Dysregulated behaviour

Aggressive outbursts, temper tantrums, self-injury

4. Overactive/impulsive

Overactivity, impulsivity, restlessness

5. Eat/sleep

Eating difficulties, sleep difficulties

6. Mood/anxiety

Anxiety, depressed mood, extreme shyness, mood swings

7. Autism spectrum disorder–like

Inflexibility, unusual language, delayed language, repetitive behaviours, poor eye contact, peer difficulties