Fig. 3

Ca²⁺/CaM-Src kinase model validation. a Cartoon schematic of Src kinase activation of the Ca²⁺/CaM signaling cascade and the pro-apoptotic protein—Bax—following hypoxic neonatal brain injury, as well as pharmacological inhibition of this pathway using PP2. b Simulation of our model yields activated Src dynamics c activated CaMKK2 (blue) and CaMKIV (cyan), d cytoplasmic (maroon) and nuclear Ca²⁺ (grey), ATP (purple), and e Bax (black) over simulation time course