From: Anxiety-like behavior and anxiolytic treatment in the Rett syndrome natural history study
Study | Feature | Any anxiolytic | SSRI | ||||
---|---|---|---|---|---|---|---|
Yes | No | Significance | Yes | No | Significance | ||
First iteration (n= 1068) | Age (years) | 11.3 ± 9.7 | 8.7 ± 8.6 | P < 0.000* | 11.3 ± 9.8 | 8.76 ± 8.6 | P < 0.000* |
CSS total score | 19.9 ± 7.1 | 22.6 ± 7.8 | P < 0.000* | 18.9 ± 6.9 | 22.7 ± 7.8 | P < 0.000* | |
MBA total score | 44.0 ± 14.1 | 47.4 ± 15.1 | P = 0.006* | 43.8 ± 14.0 | 47.4 ± 15.1 | P = 0.006* | |
Second iteration (n= 662) | Age (years) | 18.7 ± 10.6 | 14.6 ± 10.6 | P < 0.000* | 20.2 ± 10.6 | 14.5 ± 10.5 | P < 0.000* |
CSS total score | 24.0 ± 7.1 | 23.8 ± 8.5 | P = 0.790 | 23.0 ± 7.2 | 23.9 ± 8.4 | P = 0.324 | |
MBA total score | 49.7 ±13.7 | 48.6 ± 13.8 | P = 0.487 | 48.3 ± 10.7 | 48.8 ± 14.1 | P = 0.710 |