Table 1 Cleveland Clinic criteria for identifying pediatric patients who would benefit from PTEN sequencing

1. Macrocephaly (≥ 2 Standard Deviations from Mean)

AND

2. At least one of the following four additional criteria

 A. Autism or Developmental Delay

 B. Dermatologic features, including lipomas, trichilemmomas, oral papillomas, or penile freckling

 C. Vascular features, such as arteriovenous malformations or hemangiomas

 D. Gastrointestinal Polyps