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Table 3 Parameter estimates from age-based mixed models (full cohort)

From: Neuropsychological changes in FMR1 premutation carriers and onset of fragile X-associated tremor/ataxia syndrome

 

Estimate (SE)

t-value

P

Visual episodic memory (PAL errors)

 Intercept

9.47 (2.92)

3.24

.002

 Age

.356 (.168)

2.15

.034

 Group

− 2.23 (3.94)

− 0.57

.573

 Group*age

.224 (.212)

1.06

.294

Verbal episodic memory (WMS LM2 score)

 Intercept

26.89 (2.33)

11.52

.001

 Age

.084 (.107)

0.78

.435

 Group

− .762 (3.02)

− 0.25

.802

 Group*age

− .089 (.137)

− 0.65

.519

Auditory working memory (WMS LNS score)

 Intercept

13.07 (1.05)

12.4

.001

 Age

− .059 (.043)

− 1.36

.175

 Group

− .515 (1.34)

− 0.38

.702

 Group*age

− .018 (.054)

− 0.33

.740

Visual working memory (SWM errors)

 Intercept1

31.15 (5.30)

5.88

.001

 Age

− .254 (.260)

− 0.98

.330

 Group

0= (=)

=

=

 Group*age

.438 (.176)

2.49

.014+

Motor dexterity (Purdue Pegboard score)

 Intercept1

41.17 (1.18)

34.7

.001

 Age

− .150 (.061)

− 2.46

.015

 Group

0= (=)

=

=

 Group*Age

− .200 (.046)

− 4.38

.001*

Inhibitory control§ (SST reaction time)

 Intercept

527.8 (31.2)

16.9

.001

 Age

1.55 (1.78)

0.87

.358

 Group

0= (=)

=

=

 Group*age

2.94 (1.40)

2.10

.038

Visual attention (RVP score)

 Intercept

.946 (.018)

52.6

.001

 Age

− .001 (.001)

− 0.61

.544

 Group

.011 (.023)

0.47

.636

 Group*age

− .001 (.001)

− 0.96

.337

Planning (OTS score)

 Intercept

11.43 (.834)

13.7

.001

 Age

− .021 (.038)

− 0.55

.582

 Group

.147 (1.07)

0.14

.891

 Group*age

− .025 (.048)

− 0.51

.608

Executive control movement (BDS-2 score)

 Intercept

24.08 (.693)

34.7

.001

 Age

− .041 (.037)

− 1.10

.275

 Group

− .054 (.934)

− 0.06

.954

 Group*age

− .046 (.048)

− 0.97

.334

Movement time (RT)

 Intercept

217.2 (20.6)

10.5

.001

 Age

1.05 (1.15)

0.91

.367

 Group

− 15.1 (27.8)

− 0.54

.589

 Group*age

3.55 (1.47)

2.41

.018+

Reaction time (RT)

 Intercept

297.7 (14.9)

19.9

.001

 Age

1.33 (1.03)

1.29

.200

 Group

7.77 (19.1)

0.41

.684

 Group*age

1.33 (1.28)

1.04

.301

  1. “Intercept” = value at age 40 for controls except for (1), which represents value at age for overall sample. “Age” = change in value per year of age for controls. “Group” = change in intercept value for Pc compared to Nc. “Group*Age” = change in slope value for Pc relative to Nc. “0= (=)” = parameter fixed to zero. NNc = 30, 22, 20 (visit 1–visit 3); NPm = 64, 50, 37 (visit 1–visit 3). * < .05, + < .10 after Benjamini Hochberg correction for multiple comparisons