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Table 3 Parameter estimates from age-based mixed models (full cohort)

From: Neuropsychological changes in FMR1 premutation carriers and onset of fragile X-associated tremor/ataxia syndrome

  Estimate (SE) t-value P
Visual episodic memory (PAL errors)
 Intercept 9.47 (2.92) 3.24 .002
 Age .356 (.168) 2.15 .034
 Group − 2.23 (3.94) − 0.57 .573
 Group*age .224 (.212) 1.06 .294
Verbal episodic memory (WMS LM2 score)
 Intercept 26.89 (2.33) 11.52 .001
 Age .084 (.107) 0.78 .435
 Group − .762 (3.02) − 0.25 .802
 Group*age − .089 (.137) − 0.65 .519
Auditory working memory (WMS LNS score)
 Intercept 13.07 (1.05) 12.4 .001
 Age − .059 (.043) − 1.36 .175
 Group − .515 (1.34) − 0.38 .702
 Group*age − .018 (.054) − 0.33 .740
Visual working memory (SWM errors)
 Intercept1 31.15 (5.30) 5.88 .001
 Age − .254 (.260) − 0.98 .330
 Group 0= (=) = =
 Group*age .438 (.176) 2.49 .014+
Motor dexterity (Purdue Pegboard score)
 Intercept1 41.17 (1.18) 34.7 .001
 Age − .150 (.061) − 2.46 .015
 Group 0= (=) = =
 Group*Age − .200 (.046) − 4.38 .001*
Inhibitory control§ (SST reaction time)
 Intercept 527.8 (31.2) 16.9 .001
 Age 1.55 (1.78) 0.87 .358
 Group 0= (=) = =
 Group*age 2.94 (1.40) 2.10 .038
Visual attention (RVP score)
 Intercept .946 (.018) 52.6 .001
 Age − .001 (.001) − 0.61 .544
 Group .011 (.023) 0.47 .636
 Group*age − .001 (.001) − 0.96 .337
Planning (OTS score)
 Intercept 11.43 (.834) 13.7 .001
 Age − .021 (.038) − 0.55 .582
 Group .147 (1.07) 0.14 .891
 Group*age − .025 (.048) − 0.51 .608
Executive control movement (BDS-2 score)
 Intercept 24.08 (.693) 34.7 .001
 Age − .041 (.037) − 1.10 .275
 Group − .054 (.934) − 0.06 .954
 Group*age − .046 (.048) − 0.97 .334
Movement time (RT)
 Intercept 217.2 (20.6) 10.5 .001
 Age 1.05 (1.15) 0.91 .367
 Group − 15.1 (27.8) − 0.54 .589
 Group*age 3.55 (1.47) 2.41 .018+
Reaction time (RT)
 Intercept 297.7 (14.9) 19.9 .001
 Age 1.33 (1.03) 1.29 .200
 Group 7.77 (19.1) 0.41 .684
 Group*age 1.33 (1.28) 1.04 .301
  1. “Intercept” = value at age 40 for controls except for (1), which represents value at age for overall sample. “Age” = change in value per year of age for controls. “Group” = change in intercept value for Pc compared to Nc. “Group*Age” = change in slope value for Pc relative to Nc. “0= (=)” = parameter fixed to zero. NNc = 30, 22, 20 (visit 1–visit 3); NPm = 64, 50, 37 (visit 1–visit 3). * < .05, + < .10 after Benjamini Hochberg correction for multiple comparisons