The feasibility and utility of hair follicle sampling to measure FMRP and FMR1 mRNA in children with or without fragile X syndrome: a pilot study

Table 9 Relationship between FMRP levels and GARS-3 score at visit 1 — Pearson correlation coefficients

			GARS-3 Emotional Response		GARS-3 Social Communication		GARS-3 Restricted/Repetitive Behavior		GARS-3 Social Interaction		GARS-3 Cognitive Style		GARS-3 Maladaptive Speech
Collection
Group	Type	n	Pearson's r	P-value	Pearson's r	P-value	Pearson's r	P-value	Pearson's r	P-value	Pearson's r	P-value	Pearson's r	P-value
FXS Participant (N=9)	Hair Follicle	9	-0.302	0.429	0.008	0.984	-0.608	0.082	0.276	0.473	-0.204	0.629	-0.561	0.148
FXS Participant (N=9)	Blood	7	-0.203	0.663	-0.187	0.688	-0.650	0.114	0.060	0.899	-0.370	0.414	-0.790	0.035
Healthy Participant (N=5)	Hair Follicle	5	-0.017	0.978	0.062	0.921	nc		nc		-0.577	0.308		nc
Healthy Participant (N=5)	Blood	5	0.264	0.668	0.007	0.991	nc		nc		0.582	0.304		nc

Notes: For the hair follicle collection type, the mean fmol FMRP/μg protein value across all samples is correlated with each OWLS-II score or each GARS-3 score. For the buccal swab collection type, the fmol FMRP/μg protein value is not summarized as the value was “below LLOQ” for all samples
Abbreviations: GARS-3 Gilliam Autism Rating Scale 3rd Edition, nc not calculable, OWLS-II Oral and Written Language Scale 2nd Edition

ISSN: 1866-1955