Fig. 2

Manhattan plot of autism PGS in individuals of European genetic ancestries. The y-axis shows the -log10 transformed p values multiplied by the direction of effect. The dots represent the phecodes which are grouped along the X axis by phecode category. Size of the dot corresponds to the effect size. The colors of the dots indicate the phecode categories, which are explained in the figure. The dotted red line signifies the Bonferroni-corrected threshold for statistical significance