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Table 2 Pooled analysis of obstetric and neonatal characteristics

From: Intelligence, motoric and psychological outcomes in children from different ART treatments: a systematic review and meta-analysis

Characteristics

Age Group

Reporting studies

No. of Children

(cases / total)

Effect Size, p -value

Heterogeneity

(I 2 ),  p-value

ICSI

All ART

Control

Gestational Age

[mean + st. dev (no. of children)]

Toddler

14, 15, 19, 21

 

38.33 + 2.19

(422)

38.98 + 1.88

(2,371)

-0.57 [-0.81, -0.34], <0.0001

34%, 0.21

Pre-school

35 – 39, 42

39.56 + 1.47

(971)

 

39.61 + 1.55

(915)

-0.04 [-0.19, 0.10], 0.55

0%, 0.58

27, 32, 33

 

39.79 + 1.32

40.19 + 1.39

-0.40 [-0.64, -0.15], 0.002

0%, 0.74

Summary

 

39.62 + 1.43

(1,139)

39.75 + 1.51

(2,539)

-0.13 [-0.25, -0.01], 0.04

22%, 0.25

Young Adolescent

48, 49

 

38.93 + 2.48

(225)

39.60 + 1.80

(240)

-0.67 [-1.07, -0.28], 0.00009

0%, 0.85

Preterm birth

(Gestational age < 37 weeks)

Toddler

14, 23

10/76

 

13/200

2.11 [0.95, 4.66], 0.04

0%, 0.94

16, 18

 

26/165

695/10,661

2.23 [1.02, 4.87], 0.04

57%, 0.13

Summary

 

36/341

708/ 10,861

2.34 [1.65, 3.33], <0.00001

0%, 0.46

Pre-school

31,32, 34-37, 39, 42

 

62/852

38/825

1.58 [1.07, 2.32], 0.02

57%, 0.02

Young Adolescent

44 – 46, 48, 49

 

1,236/ 12,484

81,341/ 1,507,453

1.90 [1.80, 2.01], <0.00001

92%, <0.00001

Birthweight [mean + st. dev (no. of children)]

Toddler

14, 19

3,073.65 + 608.15

(76)

 

3,129.3 + 554.40

(200)

-55.65 [-220.91, 109.60], 0.51

0%, 0.96

15, 18, 21

 

3,304.89 + 655.84

(412)

3,455.56 + 601.44

(2,258)

-150.48 [-275.36, -25.60], 0.02

43%, 0.17

Summary

 

3,255.96 + 640. 54

(488)

3,359.01 + 557.51

(2,458)

-103.00 [-167.48, -38.53], 0.002

0%, 0.42

Pre-school

31, 35 – 39, 42

2,791.99 + 558.17

(999)

 

3,414.624 + 529.12

(947)

-621.97 [-672.43, -571.51], <0.00001

100%, <0.00001

27, 32, 33, 35

 

3,358.63 + 595.67

(251)

3,572.94 + 531.94

(1,763)

-213.61 [-303.09, -124.14]<0.00001

0%, 0.93

Summary

 

2,911.08 + 558.76

(1,167)

3,447.96 + 525.37

(2,625)

-538.10 [-583.05, -493.14], <0.00001

100%, <0.00001

Young Adolescent

48, 49

 

3,254.18 + 633.29

(225)

3,413.05 + 476.93

(240)

-158.89 [-261.37, -56.41], 0.002

0%, 0.45

Low Birthweight

(Birthweight < 2,500g)

Toddler

14, 16

20/140

 

572/ 10,721

2.44 [1.57, 3.79], <0.0001

0%, 0.56

Pre-school

30, 32, 34, 35

 

29/275

7/297

4.48 [1.99, 10.09], 0.0003

0%, 0.90

Young Adolescent

45, 46, 48, 49

 

956/ 11,349

31,653 / 1,502,580

3.40 [3.18, 3.64], <0.00001

95%, <0.00001