Characteristics | Age Group | Reporting studies | No. of Children (cases / total) | Effect Size, p -value | Heterogeneity (I 2 ), p-value | ||
---|---|---|---|---|---|---|---|
ICSI | All ART | Control | |||||
Gestational Age [mean + st. dev (no. of children)] | Toddler | 14, 15, 19, 21 | Â | 38.33 + 2.19 (422) | 38.98 + 1.88 (2,371) | -0.57 [-0.81, -0.34], <0.0001 | 34%, 0.21 |
Pre-school | 35 – 39, 42 | 39.56 + 1.47 (971) |  | 39.61 + 1.55 (915) | -0.04 [-0.19, 0.10], 0.55 | 0%, 0.58 | |
27, 32, 33 | Â | 39.79 + 1.32 | 40.19 + 1.39 | -0.40 [-0.64, -0.15], 0.002 | 0%, 0.74 | ||
Summary | Â | 39.62 + 1.43 (1,139) | 39.75 + 1.51 (2,539) | -0.13 [-0.25, -0.01], 0.04 | 22%, 0.25 | ||
Young Adolescent | 48, 49 | Â | 38.93 + 2.48 (225) | 39.60 + 1.80 (240) | -0.67 [-1.07, -0.28], 0.00009 | 0%, 0.85 | |
Preterm birth (Gestational age < 37 weeks) | Toddler | 14, 23 | 10/76 | Â | 13/200 | 2.11 [0.95, 4.66], 0.04 | 0%, 0.94 |
16, 18 | Â | 26/165 | 695/10,661 | 2.23 [1.02, 4.87], 0.04 | 57%, 0.13 | ||
Summary | Â | 36/341 | 708/ 10,861 | 2.34 [1.65, 3.33], <0.00001 | 0%, 0.46 | ||
Pre-school | 31,32, 34-37, 39, 42 | Â | 62/852 | 38/825 | 1.58 [1.07, 2.32], 0.02 | 57%, 0.02 | |
Young Adolescent | 44 – 46, 48, 49 |  | 1,236/ 12,484 | 81,341/ 1,507,453 | 1.90 [1.80, 2.01], <0.00001 | 92%, <0.00001 | |
Birthweight [mean + st. dev (no. of children)] | Toddler | 14, 19 | 3,073.65 + 608.15 (76) | Â | 3,129.3 + 554.40 (200) | -55.65 [-220.91, 109.60], 0.51 | 0%, 0.96 |
15, 18, 21 | Â | 3,304.89 + 655.84 (412) | 3,455.56 + 601.44 (2,258) | -150.48 [-275.36, -25.60], 0.02 | 43%, 0.17 | ||
Summary | Â | 3,255.96 + 640. 54 (488) | 3,359.01 + 557.51 (2,458) | -103.00 [-167.48, -38.53], 0.002 | 0%, 0.42 | ||
Pre-school | 31, 35 – 39, 42 | 2,791.99 + 558.17 (999) |  | 3,414.624 + 529.12 (947) | -621.97 [-672.43, -571.51], <0.00001 | 100%, <0.00001 | |
27, 32, 33, 35 | Â | 3,358.63 + 595.67 (251) | 3,572.94 + 531.94 (1,763) | -213.61 [-303.09, -124.14]<0.00001 | 0%, 0.93 | ||
Summary | Â | 2,911.08 + 558.76 (1,167) | 3,447.96 + 525.37 (2,625) | -538.10 [-583.05, -493.14], <0.00001 | 100%, <0.00001 | ||
Young Adolescent | 48, 49 | Â | 3,254.18 + 633.29 (225) | 3,413.05 + 476.93 (240) | -158.89 [-261.37, -56.41], 0.002 | 0%, 0.45 | |
Low Birthweight (Birthweight < 2,500g) | Toddler | 14, 16 | 20/140 | Â | 572/ 10,721 | 2.44 [1.57, 3.79], <0.0001 | 0%, 0.56 |
Pre-school | 30, 32, 34, 35 | Â | 29/275 | 7/297 | 4.48 [1.99, 10.09], 0.0003 | 0%, 0.90 | |
Young Adolescent | 45, 46, 48, 49 | Â | 956/ 11,349 | 31,653 / 1,502,580 | 3.40 [3.18, 3.64], <0.00001 | 95%, <0.00001 |