Fig. 4
Variation in predicted LIMK1 expression with LIMK1 haplotype in the general population (GP) groups. Violin plots demonstrating that polygenic-based prediction of LIMK1 expression in the cortex, based on postmortem expression quantitative trait locus (eQTL) data obtained from the GTEx portal (https://gtexportal.org), was very strongly dependent on haplotype group in our two GP samples. Echoing the situation in the Williams syndrome hemideletion, the Hap1 group (with reduced IPS gray matter) had lower expression scores than the Hap2 group in both A the PNC sample (N = 255, p = 10−23) and B the NIMH sample (N = 255, p = 10−15)