Fig. 1From: Enabling endpoint development for interventional clinical trials in individuals with Angelman syndrome: a prospective, longitudinal, observational clinical study (FREESIAS)FREESIAS key domains of interest in AS and study design. AÂ Key symptoms of interest in AS as identified in a previously published AS disease concept model. BÂ FREESIAS study design. The study consisted of two in-clinic visits 12Â months apart (Clinic Visit 1 and Clinic Visit 2) and three at-home visits with Home Visit 1 and 3 around the time of Clinic Visit 1 and 2, respectively and Home Visit 2 at 3Â months after Home Visit 1. AS Angelman syndrome, COA clinical outcome assessmentBack to article page