Fig. 2

Adherence/completed assessments for sleep diaries, sleep mat, actigraph, and overnight EEG. Adherence to sleep diary completion in participants with AS (A) and TDC (B). Adherence was defined as the percentage of days within the 52-week observational period in which a diary entry was recorded. Adherence to the sleep mat in participants with AS (C) and TDC (D). Shaded area in graphs A–D represents ± 1 SD. Sleep mat usage was defined as the percentage of days per week within the 52-week observational period in which a sleep mat recording was started. The number of participants included in the adherence calculation for both the sleep diary and sleep mat decreased over the 52 weeks due to either withdrawal, rollover to clinical drug trials, or early completion (see “N” above x-axis). E The percentage of nights that the actigraph was used in the Actigraphy Sleep Monitoring Period for those participants for which any data were collected (AS deletion n = 31; AS nondeletion n = 11; TDC n = 13). F Representation of wearing location of the actigraph during the home monitoring period with unknown location (black); right wrist (red); right ankle (orange); left wrist (yellow); left ankle (green); chest (light blue); abdomen (dark blue); and no actigraphy (black). The actigraph was worn for up to 10 days at home preceding and up to 2 days after the first home EEG visit. G Number of participants who completed overnight EEG recordings with usable data of at least 5 h duration at Home Visit 1, 2, and 3. AS Angelman syndrome, EEG Electroencephalogram, SD Standard deviation, TDC Typically developing children